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Molecular Mechanisms of Succinimide Formation from Aspartic Acid Residues Catalyzed by Two Water Molecules in the Aqueous Phase

Aspartic acid (Asp) residues are prone to nonenzymatic isomerization via a succinimide (Suc) intermediate. The formation of isomerized Asp residues is considered to be associated with various age-related diseases, such as cataracts and Alzheimer’s disease. In the present paper, we describe the react...

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Detalles Bibliográficos
Autores principales:	Nakayoshi, Tomoki, Kato, Koichi, Fukuyoshi, Shuichi, Takahashi, Ohgi, Kurimoto, Eiji, Oda, Akifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825500/ https://www.ncbi.nlm.nih.gov/pubmed/33419172 http://dx.doi.org/10.3390/ijms22020509

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