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Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque
A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO(2) nanocarriers (SiO(2)-(CH(2))(3)-NH(2)NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825541/ https://www.ncbi.nlm.nih.gov/pubmed/33419179 http://dx.doi.org/10.3390/molecules26020260 |
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author | Gerasymchuk, Yuriy Kałas, Wojciech Arkowski, Jacek Marciniak, Łukasz Hreniak, Dariusz Wysokińska, Edyta Strządała, Leon Obremska, Marta Tomachynski, Larysa Chernii, Viktor Stręk, Wiesław |
author_facet | Gerasymchuk, Yuriy Kałas, Wojciech Arkowski, Jacek Marciniak, Łukasz Hreniak, Dariusz Wysokińska, Edyta Strządała, Leon Obremska, Marta Tomachynski, Larysa Chernii, Viktor Stręk, Wiesław |
author_sort | Gerasymchuk, Yuriy |
collection | PubMed |
description | A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO(2) nanocarriers (SiO(2)-(CH(2))(3)-NH(2)NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO(2) conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO(2) as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease. |
format | Online Article Text |
id | pubmed-7825541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78255412021-01-24 Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque Gerasymchuk, Yuriy Kałas, Wojciech Arkowski, Jacek Marciniak, Łukasz Hreniak, Dariusz Wysokińska, Edyta Strządała, Leon Obremska, Marta Tomachynski, Larysa Chernii, Viktor Stręk, Wiesław Molecules Article A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO(2) nanocarriers (SiO(2)-(CH(2))(3)-NH(2)NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO(2) conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO(2) as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease. MDPI 2021-01-06 /pmc/articles/PMC7825541/ /pubmed/33419179 http://dx.doi.org/10.3390/molecules26020260 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gerasymchuk, Yuriy Kałas, Wojciech Arkowski, Jacek Marciniak, Łukasz Hreniak, Dariusz Wysokińska, Edyta Strządała, Leon Obremska, Marta Tomachynski, Larysa Chernii, Viktor Stręk, Wiesław Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
title | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
title_full | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
title_fullStr | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
title_full_unstemmed | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
title_short | Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO(2) Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque |
title_sort | gallato zirconium (iv) phtalocyanine complex conjugated with sio(2) nanocarrier as a photoactive drug for photodynamic therapy of atheromatic plaque |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825541/ https://www.ncbi.nlm.nih.gov/pubmed/33419179 http://dx.doi.org/10.3390/molecules26020260 |
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