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Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring

Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other sp...

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Autores principales: Danion, François, van Rhijn, Norman, Dufour, Alexandre C., Legendre, Rachel, Sismeiro, Odile, Varet, Hugo, Olivo-Marin, Jean-Christophe, Mouyna, Isabelle, Chamilos, Georgios, Bromley, Michael, Beauvais, Anne, Latgé, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825634/
https://www.ncbi.nlm.nih.gov/pubmed/33419224
http://dx.doi.org/10.3390/jof7010030
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author Danion, François
van Rhijn, Norman
Dufour, Alexandre C.
Legendre, Rachel
Sismeiro, Odile
Varet, Hugo
Olivo-Marin, Jean-Christophe
Mouyna, Isabelle
Chamilos, Georgios
Bromley, Michael
Beauvais, Anne
Latgé, Jean-Paul
author_facet Danion, François
van Rhijn, Norman
Dufour, Alexandre C.
Legendre, Rachel
Sismeiro, Odile
Varet, Hugo
Olivo-Marin, Jean-Christophe
Mouyna, Isabelle
Chamilos, Georgios
Bromley, Michael
Beauvais, Anne
Latgé, Jean-Paul
author_sort Danion, François
collection PubMed
description Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of A. fumigatus is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for A. fumigatus, the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus.
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spelling pubmed-78256342021-01-24 Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring Danion, François van Rhijn, Norman Dufour, Alexandre C. Legendre, Rachel Sismeiro, Odile Varet, Hugo Olivo-Marin, Jean-Christophe Mouyna, Isabelle Chamilos, Georgios Bromley, Michael Beauvais, Anne Latgé, Jean-Paul J Fungi (Basel) Article Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of A. fumigatus is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for A. fumigatus, the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus. MDPI 2021-01-06 /pmc/articles/PMC7825634/ /pubmed/33419224 http://dx.doi.org/10.3390/jof7010030 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Danion, François
van Rhijn, Norman
Dufour, Alexandre C.
Legendre, Rachel
Sismeiro, Odile
Varet, Hugo
Olivo-Marin, Jean-Christophe
Mouyna, Isabelle
Chamilos, Georgios
Bromley, Michael
Beauvais, Anne
Latgé, Jean-Paul
Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring
title Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring
title_full Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring
title_fullStr Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring
title_full_unstemmed Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring
title_short Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring
title_sort aspergillus fumigatus, one uninucleate species with disparate offspring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825634/
https://www.ncbi.nlm.nih.gov/pubmed/33419224
http://dx.doi.org/10.3390/jof7010030
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