Mapping the SARS-CoV-2–Host Protein–Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 Therapeutics

Protein–protein interactions (PPIs) are the vital engine of cellular machinery. After virus entry in host cells the global organization of the viral life cycle is strongly regulated by the formation of virus-host protein interactions. With the advent of high-throughput -omics platforms, the mirage t...

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Detalles Bibliográficos
Autores principales: Terracciano, Rosa, Preianò, Mariaimmacolata, Fregola, Annalisa, Pelaia, Corrado, Montalcini, Tiziana, Savino, Rocco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825748/
https://www.ncbi.nlm.nih.gov/pubmed/33430309
http://dx.doi.org/10.3390/ijms22020532

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