The presence of SARS-CoV2 antibodies in MS patients

BACKGROUND: The COVID-19 pandemic has raised novel concerns for people living with MS regarding their safety. METHODS: Observational study of patients at a single comprehensive community MS center. RESULTS: 48 patients with MS were suspected of developing COVID-19 March to May 2020; 2 died. Of the r...

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Detalles Bibliográficos
Autores principales: Wallach, Asya I., Picone, Mary Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825833/
https://www.ncbi.nlm.nih.gov/pubmed/33588315
http://dx.doi.org/10.1016/j.msard.2021.102793
Descripción
Sumario:BACKGROUND: The COVID-19 pandemic has raised novel concerns for people living with MS regarding their safety. METHODS: Observational study of patients at a single comprehensive community MS center. RESULTS: 48 patients with MS were suspected of developing COVID-19 March to May 2020; 2 died. Of the remainder, 17 were tested for COVID-19 antibodies as part of routine care. Average age of this subgroup was 49.8y ± 11.3 (age range 32-67), 76% female. 65% were treated with an anti-CD20 drug, 12% untreated, and 6% each received glatiramer acetate, interferon, natalizumab, or teriflunomide. 59% of patients were antibody negative. CONCLUSIONS: The low incidence of SARS CoV2 antibodies following infection suggests that certain DMTs may alter SARS CoV2-Ab response or persistence.

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