Cargando…

A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2), a novel coronavirus, originated as an epidemic respiratory illness in Wuhan, China. COVID-19 eventually spread to almost all countries and has now been declared a global pandemic disease by the World Health Organisation. A plethora of res...

Descripción completa

Detalles Bibliográficos
Autores principales: Siddiqui, Saquib Navid, Jayasekhar, Roland, Tshering, Sonam, Jugjali, Ranjana, Shanmugavadivel, Devipangaj, Jawed, Asheer, Rahman, Mohammed Mostafizur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825839/
https://www.ncbi.nlm.nih.gov/pubmed/33486013
http://dx.doi.org/10.1016/j.ijid.2021.01.040
_version_ 1783640401773592576
author Siddiqui, Saquib Navid
Jayasekhar, Roland
Tshering, Sonam
Jugjali, Ranjana
Shanmugavadivel, Devipangaj
Jawed, Asheer
Rahman, Mohammed Mostafizur
author_facet Siddiqui, Saquib Navid
Jayasekhar, Roland
Tshering, Sonam
Jugjali, Ranjana
Shanmugavadivel, Devipangaj
Jawed, Asheer
Rahman, Mohammed Mostafizur
author_sort Siddiqui, Saquib Navid
collection PubMed
description Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2), a novel coronavirus, originated as an epidemic respiratory illness in Wuhan, China. COVID-19 eventually spread to almost all countries and has now been declared a global pandemic disease by the World Health Organisation. A plethora of research has explored the dynamics of different clinical entities related to SARS-COV-2, in particular, COVID-19 associated coagulopathy. A large scale of patients have been reported to have developed pulmonary embolism without any other standard triggers or risk factors, leading to speculation that COVID-19 is an independent risk factor for venous thromboembolism. In addition to the development of thromboembolic complications such as pulmonary embolism, COVID-19 has also been reported to have triggered disseminated intravascular coagulation (DIC); however, it is unclear whether pulmonary embolism was due to COVID-19-induced thrombosis or a result of coagulopathy secondary to DIC. We describe a unique case of a COVID-19 associated coagulopathy in a patient with confirmed pulmonary embolism along with an overt DIC. Following diagnosis, the challenge was to identify the appropriate treatment modality for this unique situation. The patient was treated with anticoagulants and steroids along with blood products. The patient’s condition markedly improved and was clinically stable on discharge.
format Online
Article
Text
id pubmed-7825839
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
record_format MEDLINE/PubMed
spelling pubmed-78258392021-01-25 A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism Siddiqui, Saquib Navid Jayasekhar, Roland Tshering, Sonam Jugjali, Ranjana Shanmugavadivel, Devipangaj Jawed, Asheer Rahman, Mohammed Mostafizur Int J Infect Dis Case Report Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2), a novel coronavirus, originated as an epidemic respiratory illness in Wuhan, China. COVID-19 eventually spread to almost all countries and has now been declared a global pandemic disease by the World Health Organisation. A plethora of research has explored the dynamics of different clinical entities related to SARS-COV-2, in particular, COVID-19 associated coagulopathy. A large scale of patients have been reported to have developed pulmonary embolism without any other standard triggers or risk factors, leading to speculation that COVID-19 is an independent risk factor for venous thromboembolism. In addition to the development of thromboembolic complications such as pulmonary embolism, COVID-19 has also been reported to have triggered disseminated intravascular coagulation (DIC); however, it is unclear whether pulmonary embolism was due to COVID-19-induced thrombosis or a result of coagulopathy secondary to DIC. We describe a unique case of a COVID-19 associated coagulopathy in a patient with confirmed pulmonary embolism along with an overt DIC. Following diagnosis, the challenge was to identify the appropriate treatment modality for this unique situation. The patient was treated with anticoagulants and steroids along with blood products. The patient’s condition markedly improved and was clinically stable on discharge. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-03 2021-01-21 /pmc/articles/PMC7825839/ /pubmed/33486013 http://dx.doi.org/10.1016/j.ijid.2021.01.040 Text en Crown Copyright © 2021 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Siddiqui, Saquib Navid
Jayasekhar, Roland
Tshering, Sonam
Jugjali, Ranjana
Shanmugavadivel, Devipangaj
Jawed, Asheer
Rahman, Mohammed Mostafizur
A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
title A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
title_full A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
title_fullStr A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
title_full_unstemmed A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
title_short A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
title_sort unique tale of covid-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825839/
https://www.ncbi.nlm.nih.gov/pubmed/33486013
http://dx.doi.org/10.1016/j.ijid.2021.01.040
work_keys_str_mv AT siddiquisaquibnavid auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT jayasekharroland auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT tsheringsonam auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT jugjaliranjana auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT shanmugavadiveldevipangaj auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT jawedasheer auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT rahmanmohammedmostafizur auniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT siddiquisaquibnavid uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT jayasekharroland uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT tsheringsonam uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT jugjaliranjana uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT shanmugavadiveldevipangaj uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT jawedasheer uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism
AT rahmanmohammedmostafizur uniquetaleofcovid19inducedconcomitantovertdisseminatedintravascularcoagulationandacutebilateralpulmonaryembolism