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A model for COVID-19 with isolation, quarantine and testing as control measures

In this article we propose a compartmental model for the dynamics of Coronavirus Disease 2019 (COVID-19). We take into account the presence of asymptomatic infections and the main policies that have been adopted so far to contain the epidemic: social distancing, isolation of a portion of the populat...

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Autores principales: Aronna, M.S., Guglielmi, R., Moschen, L.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825862/
https://www.ncbi.nlm.nih.gov/pubmed/33540378
http://dx.doi.org/10.1016/j.epidem.2021.100437
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author Aronna, M.S.
Guglielmi, R.
Moschen, L.M.
author_facet Aronna, M.S.
Guglielmi, R.
Moschen, L.M.
author_sort Aronna, M.S.
collection PubMed
description In this article we propose a compartmental model for the dynamics of Coronavirus Disease 2019 (COVID-19). We take into account the presence of asymptomatic infections and the main policies that have been adopted so far to contain the epidemic: social distancing, isolation of a portion of the population, quarantine for confirmed cases and testing. We refer to quarantine as strict isolation, and it is applied to confirmed infected cases. In the proposed model, the proportion of people in isolation, the level of contact reduction and the testing rate are control parameters that can vary in time, representing policies that evolve in different stages. We obtain an explicit expression for the basic reproduction number [Formula: see text] in terms of the parameters of the disease and of the control policies. In this way we can quantify the effect that isolation and testing have in the evolution of the epidemic. We present a series of simulations to illustrate different realistic scenarios. From the expression of [Formula: see text] and the simulations we conclude that isolation (social distancing) and testing among asymptomatic cases are fundamental actions to control the epidemic, and the stricter these measures are and the sooner they are implemented, the more effective they are in flattening the curve of infections. Additionally, we show that people that remain in isolation significantly reduce their probability of contagion, so risk groups should be recommended to maintain a low contact rate during the course of the epidemic.
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spelling pubmed-78258622021-01-25 A model for COVID-19 with isolation, quarantine and testing as control measures Aronna, M.S. Guglielmi, R. Moschen, L.M. Epidemics Article In this article we propose a compartmental model for the dynamics of Coronavirus Disease 2019 (COVID-19). We take into account the presence of asymptomatic infections and the main policies that have been adopted so far to contain the epidemic: social distancing, isolation of a portion of the population, quarantine for confirmed cases and testing. We refer to quarantine as strict isolation, and it is applied to confirmed infected cases. In the proposed model, the proportion of people in isolation, the level of contact reduction and the testing rate are control parameters that can vary in time, representing policies that evolve in different stages. We obtain an explicit expression for the basic reproduction number [Formula: see text] in terms of the parameters of the disease and of the control policies. In this way we can quantify the effect that isolation and testing have in the evolution of the epidemic. We present a series of simulations to illustrate different realistic scenarios. From the expression of [Formula: see text] and the simulations we conclude that isolation (social distancing) and testing among asymptomatic cases are fundamental actions to control the epidemic, and the stricter these measures are and the sooner they are implemented, the more effective they are in flattening the curve of infections. Additionally, we show that people that remain in isolation significantly reduce their probability of contagion, so risk groups should be recommended to maintain a low contact rate during the course of the epidemic. The Authors. Published by Elsevier B.V. 2021-03 2021-01-21 /pmc/articles/PMC7825862/ /pubmed/33540378 http://dx.doi.org/10.1016/j.epidem.2021.100437 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Aronna, M.S.
Guglielmi, R.
Moschen, L.M.
A model for COVID-19 with isolation, quarantine and testing as control measures
title A model for COVID-19 with isolation, quarantine and testing as control measures
title_full A model for COVID-19 with isolation, quarantine and testing as control measures
title_fullStr A model for COVID-19 with isolation, quarantine and testing as control measures
title_full_unstemmed A model for COVID-19 with isolation, quarantine and testing as control measures
title_short A model for COVID-19 with isolation, quarantine and testing as control measures
title_sort model for covid-19 with isolation, quarantine and testing as control measures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825862/
https://www.ncbi.nlm.nih.gov/pubmed/33540378
http://dx.doi.org/10.1016/j.epidem.2021.100437
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