SARS-CoV-2 virus: Vaccines in development

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is an unprecedented challenge to humanity. Global herd immunity may be necessary before resumption of normal economic and societal activities. Since the beginning of the outbreak, the development of COVID-19 vaccines has proceeded at record speed...

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Detalles Bibliográficos
Autores principales: Huang, Qingrui, Yan, Jinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825979/
http://dx.doi.org/10.1016/j.fmre.2021.01.009
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author Huang, Qingrui
Yan, Jinghua
author_facet Huang, Qingrui
Yan, Jinghua
author_sort Huang, Qingrui
collection PubMed
description The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is an unprecedented challenge to humanity. Global herd immunity may be necessary before resumption of normal economic and societal activities. Since the beginning of the outbreak, the development of COVID-19 vaccines has proceeded at record speed using nearly all available platforms or strategies to maximize vaccine success. A total of 42 vaccine candidates have now entered clinical trials and encouraging data from several vaccine candidates in phase 1 or 2 clinical trials have been reported. In this review, we examine current COVID-19 vaccine candidates, discuss their strengths and weaknesses, summarize published clinical data and analyze future challenges.
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spelling pubmed-78259792021-01-25 SARS-CoV-2 virus: Vaccines in development Huang, Qingrui Yan, Jinghua Fundamental Research Review The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is an unprecedented challenge to humanity. Global herd immunity may be necessary before resumption of normal economic and societal activities. Since the beginning of the outbreak, the development of COVID-19 vaccines has proceeded at record speed using nearly all available platforms or strategies to maximize vaccine success. A total of 42 vaccine candidates have now entered clinical trials and encouraging data from several vaccine candidates in phase 1 or 2 clinical trials have been reported. In this review, we examine current COVID-19 vaccine candidates, discuss their strengths and weaknesses, summarize published clinical data and analyze future challenges. The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021-03 2021-01-22 /pmc/articles/PMC7825979/ http://dx.doi.org/10.1016/j.fmre.2021.01.009 Text en © 2021 The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Huang, Qingrui
Yan, Jinghua
SARS-CoV-2 virus: Vaccines in development
title SARS-CoV-2 virus: Vaccines in development
title_full SARS-CoV-2 virus: Vaccines in development
title_fullStr SARS-CoV-2 virus: Vaccines in development
title_full_unstemmed SARS-CoV-2 virus: Vaccines in development
title_short SARS-CoV-2 virus: Vaccines in development
title_sort sars-cov-2 virus: vaccines in development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825979/
http://dx.doi.org/10.1016/j.fmre.2021.01.009
work_keys_str_mv AT huangqingrui sarscov2virusvaccinesindevelopment
AT yanjinghua sarscov2virusvaccinesindevelopment

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