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An optimal control analysis of a COVID-19 model
This paper aims to explore the optimal control of the novel pandemic COVID-19 using non-clinical approach. We formulate a mathematical model to analyze the transmission of the infection through different human compartments. By applying a sensitivity test, we obtain the sensitivity indexes of the par...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825988/ http://dx.doi.org/10.1016/j.aej.2021.01.022 |
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author | Zamir, Muhammad Abdeljawad, Thabet Nadeem, Fawad Wahid, Abdul Yousef, Ali |
author_facet | Zamir, Muhammad Abdeljawad, Thabet Nadeem, Fawad Wahid, Abdul Yousef, Ali |
author_sort | Zamir, Muhammad |
collection | PubMed |
description | This paper aims to explore the optimal control of the novel pandemic COVID-19 using non-clinical approach. We formulate a mathematical model to analyze the transmission of the infection through different human compartments. By applying a sensitivity test, we obtain the sensitivity indexes of the parameters involved in the transmission of the disease. We demonstrate the most active/sensitive parameters to analyze the spread of the coronavirus COVID-19. The most active transmission parameters are interposed by introducing control variables. The control intervention is in the form of smart lockdown, frequent handwash, control of the disease’s side effects, face mask, and sanitizer. We Formulate Hamilton and Lagrangian to investigate the existence of the optimal control. Pontryagin’s Maximum Principle describes the control variables in the optimal control model. The objective function is designed to reduce both the infection and the cost of interventions. We use numerical simulation to verify the results of the control variables by Matlab 2019. |
format | Online Article Text |
id | pubmed-7825988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78259882021-01-25 An optimal control analysis of a COVID-19 model Zamir, Muhammad Abdeljawad, Thabet Nadeem, Fawad Wahid, Abdul Yousef, Ali Alexandria Engineering Journal Article This paper aims to explore the optimal control of the novel pandemic COVID-19 using non-clinical approach. We formulate a mathematical model to analyze the transmission of the infection through different human compartments. By applying a sensitivity test, we obtain the sensitivity indexes of the parameters involved in the transmission of the disease. We demonstrate the most active/sensitive parameters to analyze the spread of the coronavirus COVID-19. The most active transmission parameters are interposed by introducing control variables. The control intervention is in the form of smart lockdown, frequent handwash, control of the disease’s side effects, face mask, and sanitizer. We Formulate Hamilton and Lagrangian to investigate the existence of the optimal control. Pontryagin’s Maximum Principle describes the control variables in the optimal control model. The objective function is designed to reduce both the infection and the cost of interventions. We use numerical simulation to verify the results of the control variables by Matlab 2019. THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. 2021-06 2021-01-23 /pmc/articles/PMC7825988/ http://dx.doi.org/10.1016/j.aej.2021.01.022 Text en © 2021 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zamir, Muhammad Abdeljawad, Thabet Nadeem, Fawad Wahid, Abdul Yousef, Ali An optimal control analysis of a COVID-19 model |
title | An optimal control analysis of a COVID-19 model |
title_full | An optimal control analysis of a COVID-19 model |
title_fullStr | An optimal control analysis of a COVID-19 model |
title_full_unstemmed | An optimal control analysis of a COVID-19 model |
title_short | An optimal control analysis of a COVID-19 model |
title_sort | optimal control analysis of a covid-19 model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825988/ http://dx.doi.org/10.1016/j.aej.2021.01.022 |
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