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Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer

OBJECTIVE: To investigate the association between KRT17 and the prognosis in bladder cancer patients. METHODS: The clinical data of 101 patients with bladder cancer from May 2013 to May 2015 were retrospectively analyzed. At the same time, the expression of KRT17 and its correlation with clinicopath...

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Autores principales: Wu, Jiacheng, Xu, Haifei, Ji, Hao, Zhai, Baoqian, Zhu, Jinfeng, Gao, Mingde, Zhu, Haixia, Wang, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826064/
https://www.ncbi.nlm.nih.gov/pubmed/33500631
http://dx.doi.org/10.2147/OTT.S287891
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author Wu, Jiacheng
Xu, Haifei
Ji, Hao
Zhai, Baoqian
Zhu, Jinfeng
Gao, Mingde
Zhu, Haixia
Wang, Xiaolin
author_facet Wu, Jiacheng
Xu, Haifei
Ji, Hao
Zhai, Baoqian
Zhu, Jinfeng
Gao, Mingde
Zhu, Haixia
Wang, Xiaolin
author_sort Wu, Jiacheng
collection PubMed
description OBJECTIVE: To investigate the association between KRT17 and the prognosis in bladder cancer patients. METHODS: The clinical data of 101 patients with bladder cancer from May 2013 to May 2015 were retrospectively analyzed. At the same time, the expression of KRT17 and its correlation with clinicopathological factors were examined by immunohistochemistry. We search the prognostic value of KRT17 in bladder cancer from the cancer genome map (TCGA) online database. To explore the possible cellular mechanism, gene set enrichment analysis (GSEA) was used. The patients were divided into two groups: high expression of KRT17 and low expression of KRT17. The patients were followed up for 5 years to observe the survival. Kaplan–Meier method and Log rank test were used for univariate survival analysis, and Cox regression analysis was used for multivariate analysis. Finally, a nomogram was constructed on this basis for internal verification. RESULTS: Among the 101 patients, 46 (45.5%) were in the KRT17 low expression group and 55 (54.5%) in the high KRT17 expression group. After 5 years of follow-up, 79 patients survived with a survival rate of 78.2% and 22 patients died with a mortality rate of 21.8%. Kaplan–Meier survival analysis showed that OS and PFS of patients with high expression of KRT17 were significantly higher than those of patients with low expression of KRT17 (p<0.001, p=0.005). Cox multivariate analysis showed that KRT17 expression was an independent risk factor for tumor progression (p=0.019). And tumor size, vascular tumor thrombus, and T stage also affected tumor progression (p<0.05). In the internal validation, the c-index of nomogram was 0.898 (95% CI: 0.854–0.941). CONCLUSION: The decreased expression of KRT17 is associated with poor prognosis in patients with bladder cancer. KRT17 can be used as a novel predictive biomarker to provide a new therapeutic target for bladder cancer patients.
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spelling pubmed-78260642021-01-25 Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer Wu, Jiacheng Xu, Haifei Ji, Hao Zhai, Baoqian Zhu, Jinfeng Gao, Mingde Zhu, Haixia Wang, Xiaolin Onco Targets Ther Original Research OBJECTIVE: To investigate the association between KRT17 and the prognosis in bladder cancer patients. METHODS: The clinical data of 101 patients with bladder cancer from May 2013 to May 2015 were retrospectively analyzed. At the same time, the expression of KRT17 and its correlation with clinicopathological factors were examined by immunohistochemistry. We search the prognostic value of KRT17 in bladder cancer from the cancer genome map (TCGA) online database. To explore the possible cellular mechanism, gene set enrichment analysis (GSEA) was used. The patients were divided into two groups: high expression of KRT17 and low expression of KRT17. The patients were followed up for 5 years to observe the survival. Kaplan–Meier method and Log rank test were used for univariate survival analysis, and Cox regression analysis was used for multivariate analysis. Finally, a nomogram was constructed on this basis for internal verification. RESULTS: Among the 101 patients, 46 (45.5%) were in the KRT17 low expression group and 55 (54.5%) in the high KRT17 expression group. After 5 years of follow-up, 79 patients survived with a survival rate of 78.2% and 22 patients died with a mortality rate of 21.8%. Kaplan–Meier survival analysis showed that OS and PFS of patients with high expression of KRT17 were significantly higher than those of patients with low expression of KRT17 (p<0.001, p=0.005). Cox multivariate analysis showed that KRT17 expression was an independent risk factor for tumor progression (p=0.019). And tumor size, vascular tumor thrombus, and T stage also affected tumor progression (p<0.05). In the internal validation, the c-index of nomogram was 0.898 (95% CI: 0.854–0.941). CONCLUSION: The decreased expression of KRT17 is associated with poor prognosis in patients with bladder cancer. KRT17 can be used as a novel predictive biomarker to provide a new therapeutic target for bladder cancer patients. Dove 2021-01-19 /pmc/articles/PMC7826064/ /pubmed/33500631 http://dx.doi.org/10.2147/OTT.S287891 Text en © 2021 Wu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wu, Jiacheng
Xu, Haifei
Ji, Hao
Zhai, Baoqian
Zhu, Jinfeng
Gao, Mingde
Zhu, Haixia
Wang, Xiaolin
Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
title Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
title_full Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
title_fullStr Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
title_full_unstemmed Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
title_short Low Expression of Keratin17 is Related to Poor Prognosis in Bladder Cancer
title_sort low expression of keratin17 is related to poor prognosis in bladder cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826064/
https://www.ncbi.nlm.nih.gov/pubmed/33500631
http://dx.doi.org/10.2147/OTT.S287891
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