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Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine

In this study, zinc sulfide nanoparticles were loaded on reduced graphene oxide (ZnS NPs/rGO) using simple sonochemical method. The nanocomposite was characterized using different morphological and electrochemical techniques such as TEM, SEM, PXRD, EDX, Raman spectroscopy, FTIR, N(2)-adsorption–deso...

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Autores principales: Alkahtani, Saad A., Mahmoud, Ashraf M., Mahnashi, Mater H., AlQarni, Ali O., Alqahtani, Yahya S.A., El-Wekil, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826116/
https://www.ncbi.nlm.nih.gov/pubmed/33518809
http://dx.doi.org/10.1016/j.microc.2021.105972
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author Alkahtani, Saad A.
Mahmoud, Ashraf M.
Mahnashi, Mater H.
AlQarni, Ali O.
Alqahtani, Yahya S.A.
El-Wekil, Mohamed M.
author_facet Alkahtani, Saad A.
Mahmoud, Ashraf M.
Mahnashi, Mater H.
AlQarni, Ali O.
Alqahtani, Yahya S.A.
El-Wekil, Mohamed M.
author_sort Alkahtani, Saad A.
collection PubMed
description In this study, zinc sulfide nanoparticles were loaded on reduced graphene oxide (ZnS NPs/rGO) using simple sonochemical method. The nanocomposite was characterized using different morphological and electrochemical techniques such as TEM, SEM, PXRD, EDX, Raman spectroscopy, FTIR, N(2)-adsorption–desorption, CV, and EIS. The ZnS NPs/rGO modified glassy carbon electrode (GCE) was used to simultaneously estimate hydroxychloroquine (HCQ) and daclatasvir (DAC) in a binary mixture for the first time. The modified nanocomposite exhibited good catalytic activity towards HCQ and DAC detection. In addition, it showed higher sensitivity, good selectivity and stability; and high reproducibility towards HCQ and DAC analysis. The activity of the modified electrode was noticeably improved due to synergism between ZnS NPs and rGO. Under optimum conditions of DPV measurements, the anodic peak currents (Ipa) were obviously increased with the increase of HCQ and DAC amounts with linear ranges of 5.0–65.0 and 7.0–65.0 nM with LODs of 0.456 and 0.498 nM for HCQ and DAC, respectively. The ZnS NPs/ rGO modified GCE was used to quantify HCQ and DAC in biological fluids with recoveries of 98.7–102.7% and 96.9–104.5% and RSDs of 1.89–3.57% and 1.91–3.70%, respectively.
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spelling pubmed-78261162021-01-25 Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine Alkahtani, Saad A. Mahmoud, Ashraf M. Mahnashi, Mater H. AlQarni, Ali O. Alqahtani, Yahya S.A. El-Wekil, Mohamed M. Microchem J Article In this study, zinc sulfide nanoparticles were loaded on reduced graphene oxide (ZnS NPs/rGO) using simple sonochemical method. The nanocomposite was characterized using different morphological and electrochemical techniques such as TEM, SEM, PXRD, EDX, Raman spectroscopy, FTIR, N(2)-adsorption–desorption, CV, and EIS. The ZnS NPs/rGO modified glassy carbon electrode (GCE) was used to simultaneously estimate hydroxychloroquine (HCQ) and daclatasvir (DAC) in a binary mixture for the first time. The modified nanocomposite exhibited good catalytic activity towards HCQ and DAC detection. In addition, it showed higher sensitivity, good selectivity and stability; and high reproducibility towards HCQ and DAC analysis. The activity of the modified electrode was noticeably improved due to synergism between ZnS NPs and rGO. Under optimum conditions of DPV measurements, the anodic peak currents (Ipa) were obviously increased with the increase of HCQ and DAC amounts with linear ranges of 5.0–65.0 and 7.0–65.0 nM with LODs of 0.456 and 0.498 nM for HCQ and DAC, respectively. The ZnS NPs/ rGO modified GCE was used to quantify HCQ and DAC in biological fluids with recoveries of 98.7–102.7% and 96.9–104.5% and RSDs of 1.89–3.57% and 1.91–3.70%, respectively. Elsevier B.V. 2021-05 2021-01-21 /pmc/articles/PMC7826116/ /pubmed/33518809 http://dx.doi.org/10.1016/j.microc.2021.105972 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Alkahtani, Saad A.
Mahmoud, Ashraf M.
Mahnashi, Mater H.
AlQarni, Ali O.
Alqahtani, Yahya S.A.
El-Wekil, Mohamed M.
Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
title Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
title_full Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
title_fullStr Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
title_full_unstemmed Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
title_short Facile one pot sonochemical synthesis of layered nanostructure of ZnS NPs/rGO nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
title_sort facile one pot sonochemical synthesis of layered nanostructure of zns nps/rgo nanosheets for simultaneous analysis of daclatasvir and hydroxychloroquine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826116/
https://www.ncbi.nlm.nih.gov/pubmed/33518809
http://dx.doi.org/10.1016/j.microc.2021.105972
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