BAF Complex in Embryonic Stem Cells and Early Embryonic Development

Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional...

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Detalles Bibliográficos
Autores principales: Zhang, Heyao, Wang, Xuepeng, Li, Jingsheng, Shi, Ronghua, Ye, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826211/
https://www.ncbi.nlm.nih.gov/pubmed/33510794
http://dx.doi.org/10.1155/2021/6668866
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author Zhang, Heyao
Wang, Xuepeng
Li, Jingsheng
Shi, Ronghua
Ye, Ying
author_facet Zhang, Heyao
Wang, Xuepeng
Li, Jingsheng
Shi, Ronghua
Ye, Ying
author_sort Zhang, Heyao
collection PubMed
description Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional and mechanistic studies of BAF complex in mouse ESCs and early embryonic development. A discussion of the mechanistic bases underlying the distinct phenotypes upon the deletion of different BAF subunits in ESCs and embryos will be highlighted.
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spelling pubmed-78262112021-01-27 BAF Complex in Embryonic Stem Cells and Early Embryonic Development Zhang, Heyao Wang, Xuepeng Li, Jingsheng Shi, Ronghua Ye, Ying Stem Cells Int Review Article Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional and mechanistic studies of BAF complex in mouse ESCs and early embryonic development. A discussion of the mechanistic bases underlying the distinct phenotypes upon the deletion of different BAF subunits in ESCs and embryos will be highlighted. Hindawi 2021-01-16 /pmc/articles/PMC7826211/ /pubmed/33510794 http://dx.doi.org/10.1155/2021/6668866 Text en Copyright © 2021 Heyao Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Heyao
Wang, Xuepeng
Li, Jingsheng
Shi, Ronghua
Ye, Ying
BAF Complex in Embryonic Stem Cells and Early Embryonic Development
title BAF Complex in Embryonic Stem Cells and Early Embryonic Development
title_full BAF Complex in Embryonic Stem Cells and Early Embryonic Development
title_fullStr BAF Complex in Embryonic Stem Cells and Early Embryonic Development
title_full_unstemmed BAF Complex in Embryonic Stem Cells and Early Embryonic Development
title_short BAF Complex in Embryonic Stem Cells and Early Embryonic Development
title_sort baf complex in embryonic stem cells and early embryonic development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826211/
https://www.ncbi.nlm.nih.gov/pubmed/33510794
http://dx.doi.org/10.1155/2021/6668866
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AT lijingsheng bafcomplexinembryonicstemcellsandearlyembryonicdevelopment
AT shironghua bafcomplexinembryonicstemcellsandearlyembryonicdevelopment
AT yeying bafcomplexinembryonicstemcellsandearlyembryonicdevelopment

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