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A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN

Repair of covalent DNA–protein crosslinks (DPCs) by the metalloprotease SPRTN prevents genome instability, premature aging and carcinogenesis. SPRTN is specifically activated by DNA structures containing single- and double-stranded features, but degrades the protein components of DPCs promiscuously...

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Detalles Bibliográficos
Autores principales:	Zhao, Shubo, Kieser, Anja, Li, Hao-Yi, Reinking, Hannah K, Weickert, Pedro, Euteneuer, Simon, Yaneva, Denitsa, Acampora, Aleida C, Götz, Maximilian J, Feederle, Regina, Stingele, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826251/ https://www.ncbi.nlm.nih.gov/pubmed/33348378 http://dx.doi.org/10.1093/nar/gkaa1224

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