Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing

Investigations of CRISPR gene knockout editing profiles have contributed to enhanced precision of editing outcomes. However, for homology-directed repair (HDR) in particular, the editing dynamics and patterns in clinically relevant cells, such as human iPSCs and primary T cells, are poorly understoo...

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Detalles Bibliográficos
Autores principales: Fu, Ya-Wen, Dai, Xin-Yue, Wang, Wen-Tian, Yang, Zhi-Xue, Zhao, Juan-Juan, Zhang, Jian-Ping, Wen, Wei, Zhang, Feng, Oberg, Kerby C, Zhang, Lei, Cheng, Tao, Zhang, Xiao-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826255/
https://www.ncbi.nlm.nih.gov/pubmed/33398341
http://dx.doi.org/10.1093/nar/gkaa1251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826255/
https://www.ncbi.nlm.nih.gov/pubmed/33398341
http://dx.doi.org/10.1093/nar/gkaa1251

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