The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma

Well-differentiated liposarcoma (WDLPS) is a malignant neoplasia hard to diagnose and treat. Its main molecular signature is amplification of the MDM2-containing genomic region. The MDM2 oncogene is the master regulator of p53: its overexpression enhances p53 degradation and inhibits apoptosis, lead...

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Detalles Bibliográficos
Autores principales: Lago, Sara, Nadai, Matteo, Ruggiero, Emanuela, Tassinari, Martina, Marušič, Maja, Tosoni, Beatrice, Frasson, Ilaria, Cernilogar, Filippo M, Pirota, Valentina, Doria, Filippo, Plavec, Janez, Schotta, Gunnar, Richter, Sara N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826256/
https://www.ncbi.nlm.nih.gov/pubmed/33410915
http://dx.doi.org/10.1093/nar/gkaa1273

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