Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering

Replication initiator proteins (Reps) from the HUH-endonuclease superfamily process specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication in viruses, such as crop ravaging geminiviruses and human disease causing parvoviruses. In biotechnology contexts, Reps ar...

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Detalles Bibliográficos
Autores principales: Tompkins, Kassidy J, Houtti, Mo, Litzau, Lauren A, Aird, Eric J, Everett, Blake A, Nelson, Andrew T, Pornschloegl, Leland, Limón-Swanson, Lidia K, Evans, Robert L, Evans, Karen, Shi, Ke, Aihara, Hideki, Gordon, Wendy R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826260/
https://www.ncbi.nlm.nih.gov/pubmed/33410911
http://dx.doi.org/10.1093/nar/gkaa1248

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