Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents

Artemisinin-resistant malaria parasites have emerged and have been spreading, posing a significant public health challenge. Antimalarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a “selective starvation” strategy by inhibiting Plasmodium falcipar...

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Detalles Bibliográficos
Autores principales: Huang, Jian, Yuan, Yafei, Zhao, Na, Pu, Debing, Tang, Qingxuan, Zhang, Shuo, Luo, Shuchen, Yang, Xikang, Wang, Nan, Xiao, Yu, Zhang, Tuan, Liu, Zhuoyi, Sakata-Kato, Tomoyo, Jiang, Xin, Kato, Nobutaka, Yan, Nieng, Yin, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826358/
https://www.ncbi.nlm.nih.gov/pubmed/33402433
http://dx.doi.org/10.1073/pnas.2017749118

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