Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling

GPR15 is a G protein-coupled receptor (GPCR) proposed to play a role in mucosal immunity that also serves as a major entry cofactor for HIV-2 and simian immunodeficiency virus (SIV). To discover novel endogenous GPR15 ligands, we screened a hemofiltrate (HF)-derived peptide library for inhibitors of...

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Detalles Bibliográficos
Autores principales: Hayn, Manuel, Blötz, Andrea, Rodríguez, Armando, Vidal, Solange, Preising, Nico, Ständker, Ludger, Wiese, Sebastian, Stürzel, Christina M., Harms, Mirja, Gross, Rüdiger, Jung, Christoph, Kiene, Miriam, Jacob, Timo, Pöhlmann, Stefan, Forssmann, Wolf-Georg, Münch, Jan, Sparrer, Konstantin M. J., Seuwen, Klaus, Hahn, Beatrice H., Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826402/
https://www.ncbi.nlm.nih.gov/pubmed/33431697
http://dx.doi.org/10.1073/pnas.2023776118

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