HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3

Pancreatic cancer (PC) is the most malignant cancer type in the digestive system with a poor prognosis. Chemotherapy such as cisplatin is the last chance for PC patients diagnosed with advanced or metastatic disease. Obtaining a deep understanding of the molecular mechanism underlying PC tumorigenes...

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Detalles Bibliográficos
Autores principales: Hou, Xuyang, Yang, Leping, Wang, Kunpeng, Zhou, Yan, Li, Qinglong, Kong, Fanhua, Liu, Xi, He, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826454/
https://www.ncbi.nlm.nih.gov/pubmed/33280236
http://dx.doi.org/10.1002/cam4.3627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826454/
https://www.ncbi.nlm.nih.gov/pubmed/33280236
http://dx.doi.org/10.1002/cam4.3627

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