NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the...

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Detalles Bibliográficos
Autores principales: Lin, Meng-Hsuan, Huang, Yi-Ping, Chang, Chi-Fon, Hsu, Chun-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826497/
https://www.ncbi.nlm.nih.gov/pubmed/33486617
http://dx.doi.org/10.1007/s12104-020-09996-x
Descripción
Sumario:SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the (1)H, (13)C, and (15)N resonance assignments of the SARS-CoV-2 macro domain. This work provides the ground for further structural deciphering and biophysical investigation in protein function and antiviral agent design. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12104-020-09996-x) contains supplementary material, which is available to authorized users.

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