NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the...

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Autores principales: Lin, Meng-Hsuan, Huang, Yi-Ping, Chang, Chi-Fon, Hsu, Chun-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826497/
https://www.ncbi.nlm.nih.gov/pubmed/33486617
http://dx.doi.org/10.1007/s12104-020-09996-x
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author Lin, Meng-Hsuan
Huang, Yi-Ping
Chang, Chi-Fon
Hsu, Chun-Hua
author_facet Lin, Meng-Hsuan
Huang, Yi-Ping
Chang, Chi-Fon
Hsu, Chun-Hua
author_sort Lin, Meng-Hsuan
collection PubMed
description SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the (1)H, (13)C, and (15)N resonance assignments of the SARS-CoV-2 macro domain. This work provides the ground for further structural deciphering and biophysical investigation in protein function and antiviral agent design. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12104-020-09996-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-78264972021-01-25 NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Lin, Meng-Hsuan Huang, Yi-Ping Chang, Chi-Fon Hsu, Chun-Hua Biomol NMR Assign Article SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the (1)H, (13)C, and (15)N resonance assignments of the SARS-CoV-2 macro domain. This work provides the ground for further structural deciphering and biophysical investigation in protein function and antiviral agent design. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12104-020-09996-x) contains supplementary material, which is available to authorized users. Springer Netherlands 2021-01-24 2021 /pmc/articles/PMC7826497/ /pubmed/33486617 http://dx.doi.org/10.1007/s12104-020-09996-x Text en © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Lin, Meng-Hsuan
Huang, Yi-Ping
Chang, Chi-Fon
Hsu, Chun-Hua
NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
title NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
title_full NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
title_fullStr NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
title_full_unstemmed NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
title_short NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
title_sort nmr assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826497/
https://www.ncbi.nlm.nih.gov/pubmed/33486617
http://dx.doi.org/10.1007/s12104-020-09996-x
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