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Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease

There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records o...

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Autores principales: Grandone, Elvira, Pesavento, Raffaele, Tiscia, Giovanni, De Laurenzo, Antonio, Ceccato, Davide, Sartori, Maria Teresa, Mirabella, Lucia, Cinnella, Gilda, Mastroianno, Mario, Dalfino, Lidia, Colaizzo, Donatella, Vettor, Roberto, Ostuni, Angelo, Margaglione, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826536/
https://www.ncbi.nlm.nih.gov/pubmed/33440831
http://dx.doi.org/10.3390/jcm10020242
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author Grandone, Elvira
Pesavento, Raffaele
Tiscia, Giovanni
De Laurenzo, Antonio
Ceccato, Davide
Sartori, Maria Teresa
Mirabella, Lucia
Cinnella, Gilda
Mastroianno, Mario
Dalfino, Lidia
Colaizzo, Donatella
Vettor, Roberto
Ostuni, Angelo
Margaglione, Maurizio
author_facet Grandone, Elvira
Pesavento, Raffaele
Tiscia, Giovanni
De Laurenzo, Antonio
Ceccato, Davide
Sartori, Maria Teresa
Mirabella, Lucia
Cinnella, Gilda
Mastroianno, Mario
Dalfino, Lidia
Colaizzo, Donatella
Vettor, Roberto
Ostuni, Angelo
Margaglione, Maurizio
author_sort Grandone, Elvira
collection PubMed
description There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records of 422 patients admitted to medical wards or the Intensive Care Unit (ICU). In-hospital mortality occurred in 147 (34.8%) patients, 94 (63.9%) of whom were admitted to the ICU. The median fatalities age was 77 years (IQR 14). Overall, 100 patients (60 males) received transfusion during hospitalization. The overall mortality was significantly and independently associated with age, ICU admission, Chronic Kidney Disease (CKD), and the number of transfused Red Blood Cell (RBC) units. Specifically, CKD was associated with mortality in patients admitted to medical wards, whereas the number of transfused RBC units predicted mortality in those admitted to the ICU. Transfusion strongly interacted with the admission to ICU (OR: 9.9; 95% CI: 2.5–40.0). In patients with COVID-19, age is one of the strongest risk factors in predicting mortality independently of the disease’s severity. CKD confers a higher risk of mortality in patients admitted to medical wards. In those admitted to the ICU, the more RBC units are transfused, the more mortality increases.
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spelling pubmed-78265362021-01-25 Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease Grandone, Elvira Pesavento, Raffaele Tiscia, Giovanni De Laurenzo, Antonio Ceccato, Davide Sartori, Maria Teresa Mirabella, Lucia Cinnella, Gilda Mastroianno, Mario Dalfino, Lidia Colaizzo, Donatella Vettor, Roberto Ostuni, Angelo Margaglione, Maurizio J Clin Med Article There is paucity of data on the transfusion need and its impact on the overall mortality in patients with COVID-19. We explored mortality in hospitalized patients with COVID-19 who required transfusions. Information on clinical variables and in-hospital mortality were obtained from medical records of 422 patients admitted to medical wards or the Intensive Care Unit (ICU). In-hospital mortality occurred in 147 (34.8%) patients, 94 (63.9%) of whom were admitted to the ICU. The median fatalities age was 77 years (IQR 14). Overall, 100 patients (60 males) received transfusion during hospitalization. The overall mortality was significantly and independently associated with age, ICU admission, Chronic Kidney Disease (CKD), and the number of transfused Red Blood Cell (RBC) units. Specifically, CKD was associated with mortality in patients admitted to medical wards, whereas the number of transfused RBC units predicted mortality in those admitted to the ICU. Transfusion strongly interacted with the admission to ICU (OR: 9.9; 95% CI: 2.5–40.0). In patients with COVID-19, age is one of the strongest risk factors in predicting mortality independently of the disease’s severity. CKD confers a higher risk of mortality in patients admitted to medical wards. In those admitted to the ICU, the more RBC units are transfused, the more mortality increases. MDPI 2021-01-11 /pmc/articles/PMC7826536/ /pubmed/33440831 http://dx.doi.org/10.3390/jcm10020242 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grandone, Elvira
Pesavento, Raffaele
Tiscia, Giovanni
De Laurenzo, Antonio
Ceccato, Davide
Sartori, Maria Teresa
Mirabella, Lucia
Cinnella, Gilda
Mastroianno, Mario
Dalfino, Lidia
Colaizzo, Donatella
Vettor, Roberto
Ostuni, Angelo
Margaglione, Maurizio
Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease
title Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease
title_full Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease
title_fullStr Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease
title_full_unstemmed Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease
title_short Mortality and Transfusion Requirements in COVID-19 Hospitalized Italian Patients According to Severity of the Disease
title_sort mortality and transfusion requirements in covid-19 hospitalized italian patients according to severity of the disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826536/
https://www.ncbi.nlm.nih.gov/pubmed/33440831
http://dx.doi.org/10.3390/jcm10020242
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