Changes in Resurgent Sodium Current Contribute to the Hyperexcitability of Muscles in Patients with Paramyotonia Congenita

Paramyotonia congenita (PMC) is a rare hereditary skeletal muscle disorder. The major symptom, muscle stiffness, is frequently induced by cold exposure and repetitive exercise. Mutations in human SCN4A gene, which encodes the α-subunit of Na(v)1.4 channel, are responsible for PMC. Mutation screening...

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Detalles Bibliográficos
Autores principales: Huang, Chiung-Wei, Lai, Hsing-Jung, Lin, Pi-Chen, Lee, Ming-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826575/
https://www.ncbi.nlm.nih.gov/pubmed/33430134
http://dx.doi.org/10.3390/biomedicines9010051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826575/
https://www.ncbi.nlm.nih.gov/pubmed/33430134
http://dx.doi.org/10.3390/biomedicines9010051

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