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The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps

Recently, several studies explored associations between type 1 diabetes (T1DM) and microbiota. The aim of our study was to assess the colonic microbiota structure according to the metabolic control in T1DM patients treated with insulin pumps. We studied 89 T1DM patients (50.6% women) at the median a...

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Autores principales: Mrozinska, Sandra, Kapusta, Przemysław, Gosiewski, Tomasz, Sroka-Oleksiak, Agnieszka, Ludwig-Słomczyńska, Agnieszka H., Matejko, Bartłomiej, Kiec-Wilk, Beata, Bulanda, Malgorzata, Malecki, Maciej T., Wolkow, Pawel P., Klupa, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826603/
https://www.ncbi.nlm.nih.gov/pubmed/33445500
http://dx.doi.org/10.3390/microorganisms9010155
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author Mrozinska, Sandra
Kapusta, Przemysław
Gosiewski, Tomasz
Sroka-Oleksiak, Agnieszka
Ludwig-Słomczyńska, Agnieszka H.
Matejko, Bartłomiej
Kiec-Wilk, Beata
Bulanda, Malgorzata
Malecki, Maciej T.
Wolkow, Pawel P.
Klupa, Tomasz
author_facet Mrozinska, Sandra
Kapusta, Przemysław
Gosiewski, Tomasz
Sroka-Oleksiak, Agnieszka
Ludwig-Słomczyńska, Agnieszka H.
Matejko, Bartłomiej
Kiec-Wilk, Beata
Bulanda, Malgorzata
Malecki, Maciej T.
Wolkow, Pawel P.
Klupa, Tomasz
author_sort Mrozinska, Sandra
collection PubMed
description Recently, several studies explored associations between type 1 diabetes (T1DM) and microbiota. The aim of our study was to assess the colonic microbiota structure according to the metabolic control in T1DM patients treated with insulin pumps. We studied 89 T1DM patients (50.6% women) at the median age of 25 (IQR, 22–29) years. Pielou’s evenness (p = 0.02), and Shannon’s (p = 0.04) and Simpson’s diversity indexes (p = 0.01), were higher in patients with glycosylated hemoglobin (HbA1c) ≥ 53 mmol/mol (7%). There were no differences in beta diversity between groups. A linear discriminant analysis effect size (LEfSe) algorithm showed that one family (Ruminococcaceae) was enriched in patients with HbA1c < 53 mmol/mol, whereas one family (Streptococcaceae) and four species (Ruminococcus torques, unclassified species of Lactococcus, Eubacteroim dolichum, and Coprobacillus cateniformis) were enriched in patients with HbA1c ≥ 53 mmol/mol. We found that at class level, the following pathways according to Kyoto Encyclopedia of Genes and Genomes were enriched in patients with HbA1c < 53 mmol/mol: bacterial motility proteins, secretion system, bacterial secretion system, ribosome biogenesis, translation proteins, and lipid biosynthesis, whereas in patients with HbA1c ≥ 53 mmol/mol, the galactose metabolism, oxidative phosphorylation, phosphotransferase system, fructose, and mannose metabolism were enriched. Observed differences in alpha diversity, metabolic pathways, and associations between bacteria and HbA1c in colonic flora need further investigation.
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spelling pubmed-78266032021-01-25 The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps Mrozinska, Sandra Kapusta, Przemysław Gosiewski, Tomasz Sroka-Oleksiak, Agnieszka Ludwig-Słomczyńska, Agnieszka H. Matejko, Bartłomiej Kiec-Wilk, Beata Bulanda, Malgorzata Malecki, Maciej T. Wolkow, Pawel P. Klupa, Tomasz Microorganisms Article Recently, several studies explored associations between type 1 diabetes (T1DM) and microbiota. The aim of our study was to assess the colonic microbiota structure according to the metabolic control in T1DM patients treated with insulin pumps. We studied 89 T1DM patients (50.6% women) at the median age of 25 (IQR, 22–29) years. Pielou’s evenness (p = 0.02), and Shannon’s (p = 0.04) and Simpson’s diversity indexes (p = 0.01), were higher in patients with glycosylated hemoglobin (HbA1c) ≥ 53 mmol/mol (7%). There were no differences in beta diversity between groups. A linear discriminant analysis effect size (LEfSe) algorithm showed that one family (Ruminococcaceae) was enriched in patients with HbA1c < 53 mmol/mol, whereas one family (Streptococcaceae) and four species (Ruminococcus torques, unclassified species of Lactococcus, Eubacteroim dolichum, and Coprobacillus cateniformis) were enriched in patients with HbA1c ≥ 53 mmol/mol. We found that at class level, the following pathways according to Kyoto Encyclopedia of Genes and Genomes were enriched in patients with HbA1c < 53 mmol/mol: bacterial motility proteins, secretion system, bacterial secretion system, ribosome biogenesis, translation proteins, and lipid biosynthesis, whereas in patients with HbA1c ≥ 53 mmol/mol, the galactose metabolism, oxidative phosphorylation, phosphotransferase system, fructose, and mannose metabolism were enriched. Observed differences in alpha diversity, metabolic pathways, and associations between bacteria and HbA1c in colonic flora need further investigation. MDPI 2021-01-12 /pmc/articles/PMC7826603/ /pubmed/33445500 http://dx.doi.org/10.3390/microorganisms9010155 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mrozinska, Sandra
Kapusta, Przemysław
Gosiewski, Tomasz
Sroka-Oleksiak, Agnieszka
Ludwig-Słomczyńska, Agnieszka H.
Matejko, Bartłomiej
Kiec-Wilk, Beata
Bulanda, Malgorzata
Malecki, Maciej T.
Wolkow, Pawel P.
Klupa, Tomasz
The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps
title The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps
title_full The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps
title_fullStr The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps
title_full_unstemmed The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps
title_short The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps
title_sort gut microbiota profile according to glycemic control in type 1 diabetes patients treated with personal insulin pumps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826603/
https://www.ncbi.nlm.nih.gov/pubmed/33445500
http://dx.doi.org/10.3390/microorganisms9010155
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