GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation

GPR55 is a GPCR of the non-CB1/CB2 cannabinoid receptor family, which is activated by lysophosphatidylinositol (LPI) and stimulates the proliferation of cancer cells. Anandamide, a bioactive lipid endocannabinoid, acts as a biased agonist of GPR55 and induces cancer cell death, but is unstable and p...

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Detalles Bibliográficos
Autores principales: Akimov, Mikhail G., Gamisonia, Alina M., Dudina, Polina V., Gretskaya, Natalia M., Gaydaryova, Anastasia A., Kuznetsov, Andrey S., Zinchenko, Galina N., Bezuglov, Vladimir V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826688/
https://www.ncbi.nlm.nih.gov/pubmed/33435517
http://dx.doi.org/10.3390/ijms22020622

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