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Affective Temperaments and Illness Severity in Patients with Bipolar Disorder

Background and objectives: Bipolar disorder (BD) is one of the most burdensome psychiatric illnesses, being associated with a negative long-term outcome and the highest suicide rate. Although affective temperaments can impact on BD long-term outcome, their role remains poorly investigated. The aims...

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Autores principales: Luciano, Mario, Steardo, Luca, Sampogna, Gaia, Caivano, Vito, Ciampi, Carmen, Del Vecchio, Valeria, Di Cerbo, Arcangelo, Giallonardo, Vincenzo, Zinno, Francesca, De Fazio, Pasquale, Fiorillo, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826695/
https://www.ncbi.nlm.nih.gov/pubmed/33435391
http://dx.doi.org/10.3390/medicina57010054
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author Luciano, Mario
Steardo, Luca
Sampogna, Gaia
Caivano, Vito
Ciampi, Carmen
Del Vecchio, Valeria
Di Cerbo, Arcangelo
Giallonardo, Vincenzo
Zinno, Francesca
De Fazio, Pasquale
Fiorillo, Andrea
author_facet Luciano, Mario
Steardo, Luca
Sampogna, Gaia
Caivano, Vito
Ciampi, Carmen
Del Vecchio, Valeria
Di Cerbo, Arcangelo
Giallonardo, Vincenzo
Zinno, Francesca
De Fazio, Pasquale
Fiorillo, Andrea
author_sort Luciano, Mario
collection PubMed
description Background and objectives: Bipolar disorder (BD) is one of the most burdensome psychiatric illnesses, being associated with a negative long-term outcome and the highest suicide rate. Although affective temperaments can impact on BD long-term outcome, their role remains poorly investigated. The aims of the present study are to describe the clinical characteristics of patients with BD more frequently associated with the different affective temperaments and to assess the relation between affective temperaments and severity of clinical picture in a sample of patients with BD. Materials and Methods: A total of 199 patients have been recruited in the outpatients units of two university sites. Patients’ psychiatric symptoms, affective temperaments, and quality of life were investigated through validated assessment instruments. Results: Predominant cyclothymic and irritable temperaments are associated to higher number of relapses, poorer quality of life, higher rates of aggressive behaviors, and suicide attempts. Conversely, the predominant hyperthymic disposition was a protective factor for several outcome measures, including relapse rate, severity of anxiety, depressive and manic symptoms, suicidality, and earlier age at onset. One limitation of the present study is that the recruitment took place in two university sites; therefore, our findings cannot be fully generalized to the whole community of BD patients. Other limitations are the lack of a control group and the cross-sectional design of the study. Conclusions: The early identification of affective temperaments can help clinicians to identify those BD patients who are more likely to show a poor long-term outcome. An early screening of affective temperaments can be useful to develop targeted integrated pharmacological and psychosocial interventions.
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spelling pubmed-78266952021-01-25 Affective Temperaments and Illness Severity in Patients with Bipolar Disorder Luciano, Mario Steardo, Luca Sampogna, Gaia Caivano, Vito Ciampi, Carmen Del Vecchio, Valeria Di Cerbo, Arcangelo Giallonardo, Vincenzo Zinno, Francesca De Fazio, Pasquale Fiorillo, Andrea Medicina (Kaunas) Article Background and objectives: Bipolar disorder (BD) is one of the most burdensome psychiatric illnesses, being associated with a negative long-term outcome and the highest suicide rate. Although affective temperaments can impact on BD long-term outcome, their role remains poorly investigated. The aims of the present study are to describe the clinical characteristics of patients with BD more frequently associated with the different affective temperaments and to assess the relation between affective temperaments and severity of clinical picture in a sample of patients with BD. Materials and Methods: A total of 199 patients have been recruited in the outpatients units of two university sites. Patients’ psychiatric symptoms, affective temperaments, and quality of life were investigated through validated assessment instruments. Results: Predominant cyclothymic and irritable temperaments are associated to higher number of relapses, poorer quality of life, higher rates of aggressive behaviors, and suicide attempts. Conversely, the predominant hyperthymic disposition was a protective factor for several outcome measures, including relapse rate, severity of anxiety, depressive and manic symptoms, suicidality, and earlier age at onset. One limitation of the present study is that the recruitment took place in two university sites; therefore, our findings cannot be fully generalized to the whole community of BD patients. Other limitations are the lack of a control group and the cross-sectional design of the study. Conclusions: The early identification of affective temperaments can help clinicians to identify those BD patients who are more likely to show a poor long-term outcome. An early screening of affective temperaments can be useful to develop targeted integrated pharmacological and psychosocial interventions. MDPI 2021-01-09 /pmc/articles/PMC7826695/ /pubmed/33435391 http://dx.doi.org/10.3390/medicina57010054 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luciano, Mario
Steardo, Luca
Sampogna, Gaia
Caivano, Vito
Ciampi, Carmen
Del Vecchio, Valeria
Di Cerbo, Arcangelo
Giallonardo, Vincenzo
Zinno, Francesca
De Fazio, Pasquale
Fiorillo, Andrea
Affective Temperaments and Illness Severity in Patients with Bipolar Disorder
title Affective Temperaments and Illness Severity in Patients with Bipolar Disorder
title_full Affective Temperaments and Illness Severity in Patients with Bipolar Disorder
title_fullStr Affective Temperaments and Illness Severity in Patients with Bipolar Disorder
title_full_unstemmed Affective Temperaments and Illness Severity in Patients with Bipolar Disorder
title_short Affective Temperaments and Illness Severity in Patients with Bipolar Disorder
title_sort affective temperaments and illness severity in patients with bipolar disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826695/
https://www.ncbi.nlm.nih.gov/pubmed/33435391
http://dx.doi.org/10.3390/medicina57010054
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