New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689

Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds...

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Detalles Bibliográficos
Autores principales: Zhuravleva, Olesya I., Antonov, Alexandr S., Trang, Vo Thi Dieu, Pivkin, Mikhail V., Khudyakova, Yuliya V., Denisenko, Vladimir A., Popov, Roman S., Kim, Natalya Y., Yurchenko, Ekaterina A., Gerasimenko, Andrey V., Udovenko, Anatoly A., von Amsberg, Gunhild, Dyshlovoy, Sergey A., Afiyatullov, Shamil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826743/
https://www.ncbi.nlm.nih.gov/pubmed/33445521
http://dx.doi.org/10.3390/md19010032
Descripción
Sumario:Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4–6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30–39%.

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