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New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689

Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds...

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Autores principales: Zhuravleva, Olesya I., Antonov, Alexandr S., Trang, Vo Thi Dieu, Pivkin, Mikhail V., Khudyakova, Yuliya V., Denisenko, Vladimir A., Popov, Roman S., Kim, Natalya Y., Yurchenko, Ekaterina A., Gerasimenko, Andrey V., Udovenko, Anatoly A., von Amsberg, Gunhild, Dyshlovoy, Sergey A., Afiyatullov, Shamil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826743/
https://www.ncbi.nlm.nih.gov/pubmed/33445521
http://dx.doi.org/10.3390/md19010032
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author Zhuravleva, Olesya I.
Antonov, Alexandr S.
Trang, Vo Thi Dieu
Pivkin, Mikhail V.
Khudyakova, Yuliya V.
Denisenko, Vladimir A.
Popov, Roman S.
Kim, Natalya Y.
Yurchenko, Ekaterina A.
Gerasimenko, Andrey V.
Udovenko, Anatoly A.
von Amsberg, Gunhild
Dyshlovoy, Sergey A.
Afiyatullov, Shamil S.
author_facet Zhuravleva, Olesya I.
Antonov, Alexandr S.
Trang, Vo Thi Dieu
Pivkin, Mikhail V.
Khudyakova, Yuliya V.
Denisenko, Vladimir A.
Popov, Roman S.
Kim, Natalya Y.
Yurchenko, Ekaterina A.
Gerasimenko, Andrey V.
Udovenko, Anatoly A.
von Amsberg, Gunhild
Dyshlovoy, Sergey A.
Afiyatullov, Shamil S.
author_sort Zhuravleva, Olesya I.
collection PubMed
description Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4–6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30–39%.
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spelling pubmed-78267432021-01-25 New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689 Zhuravleva, Olesya I. Antonov, Alexandr S. Trang, Vo Thi Dieu Pivkin, Mikhail V. Khudyakova, Yuliya V. Denisenko, Vladimir A. Popov, Roman S. Kim, Natalya Y. Yurchenko, Ekaterina A. Gerasimenko, Andrey V. Udovenko, Anatoly A. von Amsberg, Gunhild Dyshlovoy, Sergey A. Afiyatullov, Shamil S. Mar Drugs Article Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4–6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30–39%. MDPI 2021-01-12 /pmc/articles/PMC7826743/ /pubmed/33445521 http://dx.doi.org/10.3390/md19010032 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhuravleva, Olesya I.
Antonov, Alexandr S.
Trang, Vo Thi Dieu
Pivkin, Mikhail V.
Khudyakova, Yuliya V.
Denisenko, Vladimir A.
Popov, Roman S.
Kim, Natalya Y.
Yurchenko, Ekaterina A.
Gerasimenko, Andrey V.
Udovenko, Anatoly A.
von Amsberg, Gunhild
Dyshlovoy, Sergey A.
Afiyatullov, Shamil S.
New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
title New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
title_full New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
title_fullStr New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
title_full_unstemmed New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
title_short New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689
title_sort new deoxyisoaustamide derivatives from the coral-derived fungus penicillium dimorphosporum kmm 4689
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826743/
https://www.ncbi.nlm.nih.gov/pubmed/33445521
http://dx.doi.org/10.3390/md19010032
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