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Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation

Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein–protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its ow...

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Autores principales: Kane, Emma I., Spratt, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826745/
https://www.ncbi.nlm.nih.gov/pubmed/33435370
http://dx.doi.org/10.3390/ijms22020609
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author Kane, Emma I.
Spratt, Donald E.
author_facet Kane, Emma I.
Spratt, Donald E.
author_sort Kane, Emma I.
collection PubMed
description Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein–protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence. This promiscuity allows for one AR domain to recognize and bind to a variety of intracellular substrates, suggesting that AR-containing proteins may be involved in a wide array of functions. Many AR-containing proteins serve a critical role in biological processes including the ubiquitylation signaling pathway (USP). There is also strong evidence that AR-containing protein malfunction are associated with several neurological diseases and disorders. In this review, the structure and mechanism of key AR-containing proteins are discussed to suggest and/or identify how each protein utilizes their AR domains to support ubiquitylation and the cascading pathways that follow upon substrate modification.
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spelling pubmed-78267452021-01-25 Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation Kane, Emma I. Spratt, Donald E. Int J Mol Sci Review Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein–protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence. This promiscuity allows for one AR domain to recognize and bind to a variety of intracellular substrates, suggesting that AR-containing proteins may be involved in a wide array of functions. Many AR-containing proteins serve a critical role in biological processes including the ubiquitylation signaling pathway (USP). There is also strong evidence that AR-containing protein malfunction are associated with several neurological diseases and disorders. In this review, the structure and mechanism of key AR-containing proteins are discussed to suggest and/or identify how each protein utilizes their AR domains to support ubiquitylation and the cascading pathways that follow upon substrate modification. MDPI 2021-01-09 /pmc/articles/PMC7826745/ /pubmed/33435370 http://dx.doi.org/10.3390/ijms22020609 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kane, Emma I.
Spratt, Donald E.
Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation
title Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation
title_full Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation
title_fullStr Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation
title_full_unstemmed Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation
title_short Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation
title_sort structural insights into ankyrin repeat-containing proteins and their influence in ubiquitylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826745/
https://www.ncbi.nlm.nih.gov/pubmed/33435370
http://dx.doi.org/10.3390/ijms22020609
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