The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase bioch...

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Detalles Bibliográficos
Autores principales: Wells, Carrow I., Al-Ali, Hassan, Andrews, David M., Asquith, Christopher R. M., Axtman, Alison D., Dikic, Ivan, Ebner, Daniel, Ettmayer, Peter, Fischer, Christian, Frederiksen, Mathias, Futrell, Robert E., Gray, Nathanael S., Hatch, Stephanie B., Knapp, Stefan, Lücking, Ulrich, Michaelides, Michael, Mills, Caitlin E., Müller, Susanne, Owen, Dafydd, Picado, Alfredo, Saikatendu, Kumar S., Schröder, Martin, Stolz, Alexandra, Tellechea, Mariana, Turunen, Brandon J., Vilar, Santiago, Wang, Jinhua, Zuercher, William J., Willson, Timothy M., Drewry, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826789/
https://www.ncbi.nlm.nih.gov/pubmed/33429995
http://dx.doi.org/10.3390/ijms22020566
Descripción
Sumario:We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.

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