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The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase bioch...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826789/ https://www.ncbi.nlm.nih.gov/pubmed/33429995 http://dx.doi.org/10.3390/ijms22020566 |
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| author | Wells, Carrow I. Al-Ali, Hassan Andrews, David M. Asquith, Christopher R. M. Axtman, Alison D. Dikic, Ivan Ebner, Daniel Ettmayer, Peter Fischer, Christian Frederiksen, Mathias Futrell, Robert E. Gray, Nathanael S. Hatch, Stephanie B. Knapp, Stefan Lücking, Ulrich Michaelides, Michael Mills, Caitlin E. Müller, Susanne Owen, Dafydd Picado, Alfredo Saikatendu, Kumar S. Schröder, Martin Stolz, Alexandra Tellechea, Mariana Turunen, Brandon J. Vilar, Santiago Wang, Jinhua Zuercher, William J. Willson, Timothy M. Drewry, David H. |
| author_facet | Wells, Carrow I. Al-Ali, Hassan Andrews, David M. Asquith, Christopher R. M. Axtman, Alison D. Dikic, Ivan Ebner, Daniel Ettmayer, Peter Fischer, Christian Frederiksen, Mathias Futrell, Robert E. Gray, Nathanael S. Hatch, Stephanie B. Knapp, Stefan Lücking, Ulrich Michaelides, Michael Mills, Caitlin E. Müller, Susanne Owen, Dafydd Picado, Alfredo Saikatendu, Kumar S. Schröder, Martin Stolz, Alexandra Tellechea, Mariana Turunen, Brandon J. Vilar, Santiago Wang, Jinhua Zuercher, William J. Willson, Timothy M. Drewry, David H. |
| author_sort | Wells, Carrow I. |
| collection | PubMed |
| description | We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens. |
| format | Online Article Text |
| id | pubmed-7826789 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-78267892021-01-25 The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification Wells, Carrow I. Al-Ali, Hassan Andrews, David M. Asquith, Christopher R. M. Axtman, Alison D. Dikic, Ivan Ebner, Daniel Ettmayer, Peter Fischer, Christian Frederiksen, Mathias Futrell, Robert E. Gray, Nathanael S. Hatch, Stephanie B. Knapp, Stefan Lücking, Ulrich Michaelides, Michael Mills, Caitlin E. Müller, Susanne Owen, Dafydd Picado, Alfredo Saikatendu, Kumar S. Schröder, Martin Stolz, Alexandra Tellechea, Mariana Turunen, Brandon J. Vilar, Santiago Wang, Jinhua Zuercher, William J. Willson, Timothy M. Drewry, David H. Int J Mol Sci Article We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens. MDPI 2021-01-08 /pmc/articles/PMC7826789/ /pubmed/33429995 http://dx.doi.org/10.3390/ijms22020566 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Wells, Carrow I. Al-Ali, Hassan Andrews, David M. Asquith, Christopher R. M. Axtman, Alison D. Dikic, Ivan Ebner, Daniel Ettmayer, Peter Fischer, Christian Frederiksen, Mathias Futrell, Robert E. Gray, Nathanael S. Hatch, Stephanie B. Knapp, Stefan Lücking, Ulrich Michaelides, Michael Mills, Caitlin E. Müller, Susanne Owen, Dafydd Picado, Alfredo Saikatendu, Kumar S. Schröder, Martin Stolz, Alexandra Tellechea, Mariana Turunen, Brandon J. Vilar, Santiago Wang, Jinhua Zuercher, William J. Willson, Timothy M. Drewry, David H. The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification |
| title | The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification |
| title_full | The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification |
| title_fullStr | The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification |
| title_full_unstemmed | The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification |
| title_short | The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification |
| title_sort | kinase chemogenomic set (kcgs): an open science resource for kinase vulnerability identification |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826789/ https://www.ncbi.nlm.nih.gov/pubmed/33429995 http://dx.doi.org/10.3390/ijms22020566 |
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