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Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer

Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One o...

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Autores principales: Latacz, Maria, Rozmus, Dominika, Fiedorowicz, Ewa, Snarska, Jadwiga, Jarmołowska, Beata, Kordulewska, Natalia, Savelkoul, Huub, Cieślińska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826796/
https://www.ncbi.nlm.nih.gov/pubmed/33440610
http://dx.doi.org/10.3390/nu13010200
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author Latacz, Maria
Rozmus, Dominika
Fiedorowicz, Ewa
Snarska, Jadwiga
Jarmołowska, Beata
Kordulewska, Natalia
Savelkoul, Huub
Cieślińska, Anna
author_facet Latacz, Maria
Rozmus, Dominika
Fiedorowicz, Ewa
Snarska, Jadwiga
Jarmołowska, Beata
Kordulewska, Natalia
Savelkoul, Huub
Cieślińska, Anna
author_sort Latacz, Maria
collection PubMed
description Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms underlying CRC might be the vitamin D pathway, as CRC is the most closely linked neoplasia to vitamin D deficiency. This study shows a possible association of the vitamin D receptor (VDR) polymorphisms FokI, BsmI, ApaI, and TaqI with CRC susceptibility. A total of 103 patients diagnosed with CRC (61 men and 42 women, aged 57–82 years) and 109 healthy people (50 men and 59 women, aged 47–68 years) were genotyped using PCR-RFLP for FokI, BsmI, ApaI, and TaqI. None of the single nucleotide polymorphisms (SNPs) individually increased or decreased the risk of CRC. The evaluation of haplotypes revealed two that might enhance the likelihood of CRC development: taB (OR = 30.22; 95% CI 2.81–325.31; p = 0.01) and tAb (OR = 3.84; 95% CI 1.29–11.38; p = 0.01). In conclusion, genotyping is an easy and robust procedure that needs to be performed only once in a lifetime. A creation of a relevant SNP’s panel might contribute to the identification of the groups that are at the greatest risk of CRC.
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spelling pubmed-78267962021-01-25 Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer Latacz, Maria Rozmus, Dominika Fiedorowicz, Ewa Snarska, Jadwiga Jarmołowska, Beata Kordulewska, Natalia Savelkoul, Huub Cieślińska, Anna Nutrients Article Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms underlying CRC might be the vitamin D pathway, as CRC is the most closely linked neoplasia to vitamin D deficiency. This study shows a possible association of the vitamin D receptor (VDR) polymorphisms FokI, BsmI, ApaI, and TaqI with CRC susceptibility. A total of 103 patients diagnosed with CRC (61 men and 42 women, aged 57–82 years) and 109 healthy people (50 men and 59 women, aged 47–68 years) were genotyped using PCR-RFLP for FokI, BsmI, ApaI, and TaqI. None of the single nucleotide polymorphisms (SNPs) individually increased or decreased the risk of CRC. The evaluation of haplotypes revealed two that might enhance the likelihood of CRC development: taB (OR = 30.22; 95% CI 2.81–325.31; p = 0.01) and tAb (OR = 3.84; 95% CI 1.29–11.38; p = 0.01). In conclusion, genotyping is an easy and robust procedure that needs to be performed only once in a lifetime. A creation of a relevant SNP’s panel might contribute to the identification of the groups that are at the greatest risk of CRC. MDPI 2021-01-11 /pmc/articles/PMC7826796/ /pubmed/33440610 http://dx.doi.org/10.3390/nu13010200 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Latacz, Maria
Rozmus, Dominika
Fiedorowicz, Ewa
Snarska, Jadwiga
Jarmołowska, Beata
Kordulewska, Natalia
Savelkoul, Huub
Cieślińska, Anna
Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
title Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
title_full Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
title_fullStr Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
title_full_unstemmed Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
title_short Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
title_sort vitamin d receptor (vdr) gene polymorphism in patients diagnosed with colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826796/
https://www.ncbi.nlm.nih.gov/pubmed/33440610
http://dx.doi.org/10.3390/nu13010200
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