Cargando…

Surface Modification of Fluorescent Nanodiamonds for Biological Applications

Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility. Implementation of these applications requires reliable and precis...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Hak-Sung, Neuman, Keir C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826955/
https://www.ncbi.nlm.nih.gov/pubmed/33435443
http://dx.doi.org/10.3390/nano11010153
_version_ 1783640644262035456
author Jung, Hak-Sung
Neuman, Keir C.
author_facet Jung, Hak-Sung
Neuman, Keir C.
author_sort Jung, Hak-Sung
collection PubMed
description Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility. Implementation of these applications requires reliable and precise surface functionalization. Although diamonds are generally considered inert, they typically possess diverse surface groups that permit a range of different functionalization strategies. This review provides an overview of nanodiamond surface functionalization methods including homogeneous surface termination approaches (hydrogenation, halogenation, amination, oxidation, and reduction), in addition to covalent and non-covalent surface modification with different functional moieties. Furthermore, the subsequent coupling of biomolecules onto functionalized nanodiamonds is reviewed. Finally, biomedical applications of nanodiamonds are discussed in the context of functionalization.
format Online
Article
Text
id pubmed-7826955
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78269552021-01-25 Surface Modification of Fluorescent Nanodiamonds for Biological Applications Jung, Hak-Sung Neuman, Keir C. Nanomaterials (Basel) Review Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility. Implementation of these applications requires reliable and precise surface functionalization. Although diamonds are generally considered inert, they typically possess diverse surface groups that permit a range of different functionalization strategies. This review provides an overview of nanodiamond surface functionalization methods including homogeneous surface termination approaches (hydrogenation, halogenation, amination, oxidation, and reduction), in addition to covalent and non-covalent surface modification with different functional moieties. Furthermore, the subsequent coupling of biomolecules onto functionalized nanodiamonds is reviewed. Finally, biomedical applications of nanodiamonds are discussed in the context of functionalization. MDPI 2021-01-09 /pmc/articles/PMC7826955/ /pubmed/33435443 http://dx.doi.org/10.3390/nano11010153 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jung, Hak-Sung
Neuman, Keir C.
Surface Modification of Fluorescent Nanodiamonds for Biological Applications
title Surface Modification of Fluorescent Nanodiamonds for Biological Applications
title_full Surface Modification of Fluorescent Nanodiamonds for Biological Applications
title_fullStr Surface Modification of Fluorescent Nanodiamonds for Biological Applications
title_full_unstemmed Surface Modification of Fluorescent Nanodiamonds for Biological Applications
title_short Surface Modification of Fluorescent Nanodiamonds for Biological Applications
title_sort surface modification of fluorescent nanodiamonds for biological applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826955/
https://www.ncbi.nlm.nih.gov/pubmed/33435443
http://dx.doi.org/10.3390/nano11010153
work_keys_str_mv AT junghaksung surfacemodificationoffluorescentnanodiamondsforbiologicalapplications
AT neumankeirc surfacemodificationoffluorescentnanodiamondsforbiologicalapplications