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Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria

Myosins play a key role in many cellular processes such as cell migration, adhesion, intracellular trafficking and internalization processes, making them ideal targets for bacteria. Through selected examples, such as enteropathogenic E. coli (EPEC), Neisseria, Salmonella, Shigella, Listeria or Chlam...

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Detalles Bibliográficos
Autores principales: Pillon, Margaux, Doublet, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826972/
https://www.ncbi.nlm.nih.gov/pubmed/33435466
http://dx.doi.org/10.3390/ijms22020615
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author Pillon, Margaux
Doublet, Patricia
author_facet Pillon, Margaux
Doublet, Patricia
author_sort Pillon, Margaux
collection PubMed
description Myosins play a key role in many cellular processes such as cell migration, adhesion, intracellular trafficking and internalization processes, making them ideal targets for bacteria. Through selected examples, such as enteropathogenic E. coli (EPEC), Neisseria, Salmonella, Shigella, Listeria or Chlamydia, this review aims to illustrate how bacteria target and hijack host cell myosins in order to adhere to the cell, to enter the cell by triggering their internalization, to evade from the cytosolic autonomous cell defense, to promote the biogenesis of intracellular replicative niche, to disseminate in tissues by cell-to-cell spreading, to exit out the host cell, and also to evade from macrophage phagocytosis. It highlights the diversity and sophistication of the strategy evolved by bacteria to manipulate one of their privileged targets, the actin cytoskeleton.
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spelling pubmed-78269722021-01-25 Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria Pillon, Margaux Doublet, Patricia Int J Mol Sci Review Myosins play a key role in many cellular processes such as cell migration, adhesion, intracellular trafficking and internalization processes, making them ideal targets for bacteria. Through selected examples, such as enteropathogenic E. coli (EPEC), Neisseria, Salmonella, Shigella, Listeria or Chlamydia, this review aims to illustrate how bacteria target and hijack host cell myosins in order to adhere to the cell, to enter the cell by triggering their internalization, to evade from the cytosolic autonomous cell defense, to promote the biogenesis of intracellular replicative niche, to disseminate in tissues by cell-to-cell spreading, to exit out the host cell, and also to evade from macrophage phagocytosis. It highlights the diversity and sophistication of the strategy evolved by bacteria to manipulate one of their privileged targets, the actin cytoskeleton. MDPI 2021-01-09 /pmc/articles/PMC7826972/ /pubmed/33435466 http://dx.doi.org/10.3390/ijms22020615 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pillon, Margaux
Doublet, Patricia
Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
title Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
title_full Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
title_fullStr Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
title_full_unstemmed Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
title_short Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
title_sort myosins, an underestimated player in the infectious cycle of pathogenic bacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826972/
https://www.ncbi.nlm.nih.gov/pubmed/33435466
http://dx.doi.org/10.3390/ijms22020615
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