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Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria
Myosins play a key role in many cellular processes such as cell migration, adhesion, intracellular trafficking and internalization processes, making them ideal targets for bacteria. Through selected examples, such as enteropathogenic E. coli (EPEC), Neisseria, Salmonella, Shigella, Listeria or Chlam...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826972/ https://www.ncbi.nlm.nih.gov/pubmed/33435466 http://dx.doi.org/10.3390/ijms22020615 |
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author | Pillon, Margaux Doublet, Patricia |
author_facet | Pillon, Margaux Doublet, Patricia |
author_sort | Pillon, Margaux |
collection | PubMed |
description | Myosins play a key role in many cellular processes such as cell migration, adhesion, intracellular trafficking and internalization processes, making them ideal targets for bacteria. Through selected examples, such as enteropathogenic E. coli (EPEC), Neisseria, Salmonella, Shigella, Listeria or Chlamydia, this review aims to illustrate how bacteria target and hijack host cell myosins in order to adhere to the cell, to enter the cell by triggering their internalization, to evade from the cytosolic autonomous cell defense, to promote the biogenesis of intracellular replicative niche, to disseminate in tissues by cell-to-cell spreading, to exit out the host cell, and also to evade from macrophage phagocytosis. It highlights the diversity and sophistication of the strategy evolved by bacteria to manipulate one of their privileged targets, the actin cytoskeleton. |
format | Online Article Text |
id | pubmed-7826972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78269722021-01-25 Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria Pillon, Margaux Doublet, Patricia Int J Mol Sci Review Myosins play a key role in many cellular processes such as cell migration, adhesion, intracellular trafficking and internalization processes, making them ideal targets for bacteria. Through selected examples, such as enteropathogenic E. coli (EPEC), Neisseria, Salmonella, Shigella, Listeria or Chlamydia, this review aims to illustrate how bacteria target and hijack host cell myosins in order to adhere to the cell, to enter the cell by triggering their internalization, to evade from the cytosolic autonomous cell defense, to promote the biogenesis of intracellular replicative niche, to disseminate in tissues by cell-to-cell spreading, to exit out the host cell, and also to evade from macrophage phagocytosis. It highlights the diversity and sophistication of the strategy evolved by bacteria to manipulate one of their privileged targets, the actin cytoskeleton. MDPI 2021-01-09 /pmc/articles/PMC7826972/ /pubmed/33435466 http://dx.doi.org/10.3390/ijms22020615 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pillon, Margaux Doublet, Patricia Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria |
title | Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria |
title_full | Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria |
title_fullStr | Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria |
title_full_unstemmed | Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria |
title_short | Myosins, an Underestimated Player in the Infectious Cycle of Pathogenic Bacteria |
title_sort | myosins, an underestimated player in the infectious cycle of pathogenic bacteria |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826972/ https://www.ncbi.nlm.nih.gov/pubmed/33435466 http://dx.doi.org/10.3390/ijms22020615 |
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