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Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols

Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is comple...

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Detalles Bibliográficos
Autores principales: Van Buiten, Charlene B., Elias, Ryan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826989/
https://www.ncbi.nlm.nih.gov/pubmed/33435615
http://dx.doi.org/10.3390/ijms22020595
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author Van Buiten, Charlene B.
Elias, Ryan J.
author_facet Van Buiten, Charlene B.
Elias, Ryan J.
author_sort Van Buiten, Charlene B.
collection PubMed
description Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method.
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spelling pubmed-78269892021-01-25 Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols Van Buiten, Charlene B. Elias, Ryan J. Int J Mol Sci Review Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method. MDPI 2021-01-08 /pmc/articles/PMC7826989/ /pubmed/33435615 http://dx.doi.org/10.3390/ijms22020595 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Van Buiten, Charlene B.
Elias, Ryan J.
Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
title Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
title_full Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
title_fullStr Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
title_full_unstemmed Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
title_short Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
title_sort gliadin sequestration as a novel therapy for celiac disease: a prospective application for polyphenols
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826989/
https://www.ncbi.nlm.nih.gov/pubmed/33435615
http://dx.doi.org/10.3390/ijms22020595
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