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Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore...

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Autores principales: Barandouzi, Zahra A., Lee, Joochul, Maas, Kendra, Starkweather, Angela R., Cong, Xiaomei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827153/
https://www.ncbi.nlm.nih.gov/pubmed/33429936
http://dx.doi.org/10.3390/jpm11010035
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author Barandouzi, Zahra A.
Lee, Joochul
Maas, Kendra
Starkweather, Angela R.
Cong, Xiaomei S.
author_facet Barandouzi, Zahra A.
Lee, Joochul
Maas, Kendra
Starkweather, Angela R.
Cong, Xiaomei S.
author_sort Barandouzi, Zahra A.
collection PubMed
description The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.
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spelling pubmed-78271532021-01-25 Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components Barandouzi, Zahra A. Lee, Joochul Maas, Kendra Starkweather, Angela R. Cong, Xiaomei S. J Pers Med Article The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study. MDPI 2021-01-08 /pmc/articles/PMC7827153/ /pubmed/33429936 http://dx.doi.org/10.3390/jpm11010035 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barandouzi, Zahra A.
Lee, Joochul
Maas, Kendra
Starkweather, Angela R.
Cong, Xiaomei S.
Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
title Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
title_full Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
title_fullStr Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
title_full_unstemmed Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
title_short Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
title_sort altered gut microbiota in irritable bowel syndrome and its association with food components
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827153/
https://www.ncbi.nlm.nih.gov/pubmed/33429936
http://dx.doi.org/10.3390/jpm11010035
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