Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors

Since exacerbated inflammation and microvascular leakage are hallmarks of dengue virus (DENV) infection, here we interrogated whether systemic activation of the contact/kallikrein-kinin system (KKS) might hamper endothelial function. In vitro assays showed that dextran sulfate, a potent contact acti...

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Detalles Bibliográficos
Autores principales: Coelho, Sharton V. A., Rust, Naiara M., Vellasco, Lucas, Papa, Michelle P., Pereira, Aline S. G., da Silva Palazzo, Matheus Ferreira, Juliano, Maria Aparecida, Costa, Simone M., Alves, Ada M. B., Cordeiro, Marli T., Marques, Ernesto T. A., Scharfstein, Júlio, de Arruda, Luciana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827195/
https://www.ncbi.nlm.nih.gov/pubmed/33445640
http://dx.doi.org/10.3390/ph14010056

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