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Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi

Mycoses still represent relevant opportunistic infections worldwide, although overshadowed in recent years by other severe and more widespread infections. Moreover, deep-seated mycoses are often accompanied by unacceptably high mortality rates. Etiologic agents include endogenous components of the m...

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Autores principales: Ciociola, Tecla, Giovati, Laura, Conti, Stefania, Magliani, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827253/
https://www.ncbi.nlm.nih.gov/pubmed/33435157
http://dx.doi.org/10.3390/microorganisms9010143
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author Ciociola, Tecla
Giovati, Laura
Conti, Stefania
Magliani, Walter
author_facet Ciociola, Tecla
Giovati, Laura
Conti, Stefania
Magliani, Walter
author_sort Ciociola, Tecla
collection PubMed
description Mycoses still represent relevant opportunistic infections worldwide, although overshadowed in recent years by other severe and more widespread infections. Moreover, deep-seated mycoses are often accompanied by unacceptably high mortality rates. Etiologic agents include endogenous components of the mycobiota, Candida and Malassezia species above all, and exogenous species, both yeasts and filamentous fungi. Old and new fungal pathogens are increasingly characterized by resistance to the existing antifungal agents, making imperative the search for effective and safe new therapeutics. Among the candidate molecules proposed in recent decades, synthetic peptides derived from the complementarity determining and constant regions of diverse antibodies (Abs), as well as the translated products of Ab-encoding genes, have proved of considerable interest. Their anti-infective activities, regardless of the specificity and isotype of the originating Ab, will be briefly presented and discussed in the light of their different mechanisms of action. Intriguing suggestions on the possible function of Abs after their half-life will be presented, following the recent detection, in human serum, of an antimicrobial Ab-derived peptide. Overall, Abs could represent a source of biologically active, highly flexible peptides, devoid of detectable toxicity, which can be easily synthesized and manipulated to be used, alone or in association with already available drugs, for new anti-infective strategies.
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spelling pubmed-78272532021-01-25 Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi Ciociola, Tecla Giovati, Laura Conti, Stefania Magliani, Walter Microorganisms Review Mycoses still represent relevant opportunistic infections worldwide, although overshadowed in recent years by other severe and more widespread infections. Moreover, deep-seated mycoses are often accompanied by unacceptably high mortality rates. Etiologic agents include endogenous components of the mycobiota, Candida and Malassezia species above all, and exogenous species, both yeasts and filamentous fungi. Old and new fungal pathogens are increasingly characterized by resistance to the existing antifungal agents, making imperative the search for effective and safe new therapeutics. Among the candidate molecules proposed in recent decades, synthetic peptides derived from the complementarity determining and constant regions of diverse antibodies (Abs), as well as the translated products of Ab-encoding genes, have proved of considerable interest. Their anti-infective activities, regardless of the specificity and isotype of the originating Ab, will be briefly presented and discussed in the light of their different mechanisms of action. Intriguing suggestions on the possible function of Abs after their half-life will be presented, following the recent detection, in human serum, of an antimicrobial Ab-derived peptide. Overall, Abs could represent a source of biologically active, highly flexible peptides, devoid of detectable toxicity, which can be easily synthesized and manipulated to be used, alone or in association with already available drugs, for new anti-infective strategies. MDPI 2021-01-10 /pmc/articles/PMC7827253/ /pubmed/33435157 http://dx.doi.org/10.3390/microorganisms9010143 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ciociola, Tecla
Giovati, Laura
Conti, Stefania
Magliani, Walter
Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi
title Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi
title_full Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi
title_fullStr Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi
title_full_unstemmed Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi
title_short Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi
title_sort anti-infective antibody-derived peptides active against endogenous and exogenous fungi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827253/
https://www.ncbi.nlm.nih.gov/pubmed/33435157
http://dx.doi.org/10.3390/microorganisms9010143
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