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Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases

Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this speci...

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Detalles Bibliográficos
Autores principales: Yoshida, Toru, Tsuge, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827354/
https://www.ncbi.nlm.nih.gov/pubmed/33430384
http://dx.doi.org/10.3390/toxins13010040
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author Yoshida, Toru
Tsuge, Hideaki
author_facet Yoshida, Toru
Tsuge, Hideaki
author_sort Yoshida, Toru
collection PubMed
description Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this specificity is poorly understood. Here, we review the substrate recognition mechanism and target residue specificity based on the available complex structures of ARTs and their substrates. We show that there are common mechanisms of target residue specificity among protein- and DNA-targeting ARTs.
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spelling pubmed-78273542021-01-25 Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases Yoshida, Toru Tsuge, Hideaki Toxins (Basel) Review Many bacterial pathogens utilize ADP-ribosyltransferases (ARTs) as virulence factors. The critical aspect of ARTs is their target specificity. Each individual ART modifies a specific residue of its substrates, which could be proteins, DNA, or antibiotics. However, the mechanism underlying this specificity is poorly understood. Here, we review the substrate recognition mechanism and target residue specificity based on the available complex structures of ARTs and their substrates. We show that there are common mechanisms of target residue specificity among protein- and DNA-targeting ARTs. MDPI 2021-01-07 /pmc/articles/PMC7827354/ /pubmed/33430384 http://dx.doi.org/10.3390/toxins13010040 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yoshida, Toru
Tsuge, Hideaki
Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases
title Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases
title_full Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases
title_fullStr Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases
title_full_unstemmed Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases
title_short Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases
title_sort common mechanism for target specificity of protein- and dna-targeting adp-ribosyltransferases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827354/
https://www.ncbi.nlm.nih.gov/pubmed/33430384
http://dx.doi.org/10.3390/toxins13010040
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