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Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies
Protein arginine methylation is a common post-translational modification that plays a pivotal role in cellular regulation. Protein arginine methyltransferases (PRMTs) catalyze the modification of target proteins by adding methyl groups to the guanidino nitrogen atoms of arginine residues. Protein ar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827394/ https://www.ncbi.nlm.nih.gov/pubmed/33440687 http://dx.doi.org/10.3390/cells10010124 |
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author | Bryant, Jean-Paul Heiss, John Banasavadi-Siddegowda, Yeshavanth Kumar |
author_facet | Bryant, Jean-Paul Heiss, John Banasavadi-Siddegowda, Yeshavanth Kumar |
author_sort | Bryant, Jean-Paul |
collection | PubMed |
description | Protein arginine methylation is a common post-translational modification that plays a pivotal role in cellular regulation. Protein arginine methyltransferases (PRMTs) catalyze the modification of target proteins by adding methyl groups to the guanidino nitrogen atoms of arginine residues. Protein arginine methylation takes part in epigenetic and cellular regulation and has been linked to neurodegenerative diseases, metabolic diseases, and tumor progression. Aberrant expression of PRMTs is associated with the development of brain tumors such as glioblastoma and medulloblastoma. Identifying PRMTs as plausible contributors to tumorigenesis has led to preclinical and clinical investigations of PRMT inhibitors for glioblastoma and medulloblastoma therapy. In this review, we discuss the role of arginine methylation in cancer biology and provide an update on the use of small molecule inhibitors of PRMTs to treat glioblastoma, medulloblastoma, and other cancers. |
format | Online Article Text |
id | pubmed-7827394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78273942021-01-25 Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies Bryant, Jean-Paul Heiss, John Banasavadi-Siddegowda, Yeshavanth Kumar Cells Review Protein arginine methylation is a common post-translational modification that plays a pivotal role in cellular regulation. Protein arginine methyltransferases (PRMTs) catalyze the modification of target proteins by adding methyl groups to the guanidino nitrogen atoms of arginine residues. Protein arginine methylation takes part in epigenetic and cellular regulation and has been linked to neurodegenerative diseases, metabolic diseases, and tumor progression. Aberrant expression of PRMTs is associated with the development of brain tumors such as glioblastoma and medulloblastoma. Identifying PRMTs as plausible contributors to tumorigenesis has led to preclinical and clinical investigations of PRMT inhibitors for glioblastoma and medulloblastoma therapy. In this review, we discuss the role of arginine methylation in cancer biology and provide an update on the use of small molecule inhibitors of PRMTs to treat glioblastoma, medulloblastoma, and other cancers. MDPI 2021-01-11 /pmc/articles/PMC7827394/ /pubmed/33440687 http://dx.doi.org/10.3390/cells10010124 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bryant, Jean-Paul Heiss, John Banasavadi-Siddegowda, Yeshavanth Kumar Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies |
title | Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies |
title_full | Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies |
title_fullStr | Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies |
title_full_unstemmed | Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies |
title_short | Arginine Methylation in Brain Tumors: Tumor Biology and Therapeutic Strategies |
title_sort | arginine methylation in brain tumors: tumor biology and therapeutic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827394/ https://www.ncbi.nlm.nih.gov/pubmed/33440687 http://dx.doi.org/10.3390/cells10010124 |
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