Cargando…
Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presenc...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827420/ https://www.ncbi.nlm.nih.gov/pubmed/33430492 http://dx.doi.org/10.3390/jcm10020199 |
_version_ | 1783640758013657088 |
---|---|
author | Tudoran, Cristina Tudoran, Mariana Lazureanu, Voichita Elena Marinescu, Adelina Raluca Pop, Gheorghe Nicusor Pescariu, Alexandru Silvius Enache, Alexandra Cut, Talida Georgiana |
author_facet | Tudoran, Cristina Tudoran, Mariana Lazureanu, Voichita Elena Marinescu, Adelina Raluca Pop, Gheorghe Nicusor Pescariu, Alexandru Silvius Enache, Alexandra Cut, Talida Georgiana |
author_sort | Tudoran, Cristina |
collection | PubMed |
description | Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presence of an increased estimated systolic pressure in the pulmonary artery (esPAP) and altered right ventricular global longitudinal strain (RV-GLS) in patients without history of PH. Methods: In a group of 91 patients, aged under 55 years, hospitalized for a moderate Covid-19 infection, a thorough cardiologic and TTE examination were performed two months after discharge. Their initial thorax computer-tomography (TCT) images and laboratory data were accessed from the electronic data base of the hospital. Results: We observed an increased prevalence of PH (7.69%) and RVD (10.28%), significantly correlated with the initial levels of the TCT score and inflammatory factors (p ˂ 0.001), but borderline changes were observed in more patients. Multivariate regression analysis showed that these factors and RV-GLS explain 89.5% of elevated esPAP. Conclusions: In COVID-19 infection, PH and RVD are common complications, being encountered after the recovery even in moderate cases. It appears to be a connection between their severity and the extent of the initial pulmonary injury and of the inflammatory response. |
format | Online Article Text |
id | pubmed-7827420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78274202021-01-25 Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology Tudoran, Cristina Tudoran, Mariana Lazureanu, Voichita Elena Marinescu, Adelina Raluca Pop, Gheorghe Nicusor Pescariu, Alexandru Silvius Enache, Alexandra Cut, Talida Georgiana J Clin Med Article Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presence of an increased estimated systolic pressure in the pulmonary artery (esPAP) and altered right ventricular global longitudinal strain (RV-GLS) in patients without history of PH. Methods: In a group of 91 patients, aged under 55 years, hospitalized for a moderate Covid-19 infection, a thorough cardiologic and TTE examination were performed two months after discharge. Their initial thorax computer-tomography (TCT) images and laboratory data were accessed from the electronic data base of the hospital. Results: We observed an increased prevalence of PH (7.69%) and RVD (10.28%), significantly correlated with the initial levels of the TCT score and inflammatory factors (p ˂ 0.001), but borderline changes were observed in more patients. Multivariate regression analysis showed that these factors and RV-GLS explain 89.5% of elevated esPAP. Conclusions: In COVID-19 infection, PH and RVD are common complications, being encountered after the recovery even in moderate cases. It appears to be a connection between their severity and the extent of the initial pulmonary injury and of the inflammatory response. MDPI 2021-01-07 /pmc/articles/PMC7827420/ /pubmed/33430492 http://dx.doi.org/10.3390/jcm10020199 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tudoran, Cristina Tudoran, Mariana Lazureanu, Voichita Elena Marinescu, Adelina Raluca Pop, Gheorghe Nicusor Pescariu, Alexandru Silvius Enache, Alexandra Cut, Talida Georgiana Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
title | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
title_full | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
title_fullStr | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
title_full_unstemmed | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
title_short | Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology |
title_sort | evidence of pulmonary hypertension after sars-cov-2 infection in subjects without previous significant cardiovascular pathology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827420/ https://www.ncbi.nlm.nih.gov/pubmed/33430492 http://dx.doi.org/10.3390/jcm10020199 |
work_keys_str_mv | AT tudorancristina evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT tudoranmariana evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT lazureanuvoichitaelena evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT marinescuadelinaraluca evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT popgheorghenicusor evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT pescariualexandrusilvius evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT enachealexandra evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology AT cuttalidageorgiana evidenceofpulmonaryhypertensionaftersarscov2infectioninsubjectswithoutprevioussignificantcardiovascularpathology |