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Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology

Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presenc...

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Autores principales: Tudoran, Cristina, Tudoran, Mariana, Lazureanu, Voichita Elena, Marinescu, Adelina Raluca, Pop, Gheorghe Nicusor, Pescariu, Alexandru Silvius, Enache, Alexandra, Cut, Talida Georgiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827420/
https://www.ncbi.nlm.nih.gov/pubmed/33430492
http://dx.doi.org/10.3390/jcm10020199
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author Tudoran, Cristina
Tudoran, Mariana
Lazureanu, Voichita Elena
Marinescu, Adelina Raluca
Pop, Gheorghe Nicusor
Pescariu, Alexandru Silvius
Enache, Alexandra
Cut, Talida Georgiana
author_facet Tudoran, Cristina
Tudoran, Mariana
Lazureanu, Voichita Elena
Marinescu, Adelina Raluca
Pop, Gheorghe Nicusor
Pescariu, Alexandru Silvius
Enache, Alexandra
Cut, Talida Georgiana
author_sort Tudoran, Cristina
collection PubMed
description Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presence of an increased estimated systolic pressure in the pulmonary artery (esPAP) and altered right ventricular global longitudinal strain (RV-GLS) in patients without history of PH. Methods: In a group of 91 patients, aged under 55 years, hospitalized for a moderate Covid-19 infection, a thorough cardiologic and TTE examination were performed two months after discharge. Their initial thorax computer-tomography (TCT) images and laboratory data were accessed from the electronic data base of the hospital. Results: We observed an increased prevalence of PH (7.69%) and RVD (10.28%), significantly correlated with the initial levels of the TCT score and inflammatory factors (p ˂ 0.001), but borderline changes were observed in more patients. Multivariate regression analysis showed that these factors and RV-GLS explain 89.5% of elevated esPAP. Conclusions: In COVID-19 infection, PH and RVD are common complications, being encountered after the recovery even in moderate cases. It appears to be a connection between their severity and the extent of the initial pulmonary injury and of the inflammatory response.
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spelling pubmed-78274202021-01-25 Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology Tudoran, Cristina Tudoran, Mariana Lazureanu, Voichita Elena Marinescu, Adelina Raluca Pop, Gheorghe Nicusor Pescariu, Alexandru Silvius Enache, Alexandra Cut, Talida Georgiana J Clin Med Article Background: Coronavirus (Covid-19) infection represents a serious medical condition, often associated with cardiovascular complications, pulmonary hypertension (PH), and right ventricle dysfunction (RVD). The aim of this study is to show, by means of transthoracic echocardiography (TTE), the presence of an increased estimated systolic pressure in the pulmonary artery (esPAP) and altered right ventricular global longitudinal strain (RV-GLS) in patients without history of PH. Methods: In a group of 91 patients, aged under 55 years, hospitalized for a moderate Covid-19 infection, a thorough cardiologic and TTE examination were performed two months after discharge. Their initial thorax computer-tomography (TCT) images and laboratory data were accessed from the electronic data base of the hospital. Results: We observed an increased prevalence of PH (7.69%) and RVD (10.28%), significantly correlated with the initial levels of the TCT score and inflammatory factors (p ˂ 0.001), but borderline changes were observed in more patients. Multivariate regression analysis showed that these factors and RV-GLS explain 89.5% of elevated esPAP. Conclusions: In COVID-19 infection, PH and RVD are common complications, being encountered after the recovery even in moderate cases. It appears to be a connection between their severity and the extent of the initial pulmonary injury and of the inflammatory response. MDPI 2021-01-07 /pmc/articles/PMC7827420/ /pubmed/33430492 http://dx.doi.org/10.3390/jcm10020199 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tudoran, Cristina
Tudoran, Mariana
Lazureanu, Voichita Elena
Marinescu, Adelina Raluca
Pop, Gheorghe Nicusor
Pescariu, Alexandru Silvius
Enache, Alexandra
Cut, Talida Georgiana
Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
title Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
title_full Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
title_fullStr Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
title_full_unstemmed Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
title_short Evidence of Pulmonary Hypertension after SARS-CoV-2 Infection in Subjects without Previous Significant Cardiovascular Pathology
title_sort evidence of pulmonary hypertension after sars-cov-2 infection in subjects without previous significant cardiovascular pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827420/
https://www.ncbi.nlm.nih.gov/pubmed/33430492
http://dx.doi.org/10.3390/jcm10020199
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