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Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii

Bafilomycin A(1) is the representative compound of the plecomacrolide natural product family. This 16-membered ring plecomacrolide has potent antifungal and vacuolar H(+)-ATPase inhibitory activities. In our previous work, we identified a bafilomycin biosynthetic gene cluster (baf) from the marine b...

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Detalles Bibliográficos
Autores principales:	Li, Zhong, Li, Shuai, Du, Lei, Zhang, Xingwang, Jiang, Yuanyuan, Liu, Wenhua, Zhang, Wei, Li, Shengying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827423/ https://www.ncbi.nlm.nih.gov/pubmed/33440628 http://dx.doi.org/10.3390/md19010029

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