Inflammation in the Human Periodontium Induces Downregulation of the α(1)- and β(1)-Subunits of the sGC in Cementoclasts

Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. N...

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Detalles Bibliográficos
Autores principales: Korkmaz, Yüksel, Puladi, Behrus, Galler, Kerstin, Kämmerer, Peer W., Schröder, Agnes, Gölz, Lina, Sparwasser, Tim, Bloch, Wilhelm, Friebe, Andreas, Deschner, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827426/
https://www.ncbi.nlm.nih.gov/pubmed/33430449
http://dx.doi.org/10.3390/ijms22020539

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