Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future

Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journ...

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Detalles Bibliográficos
Autores principales: Minciacchi, Valentina R., Kumar, Rahul, Krause, Daniela S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827482/
https://www.ncbi.nlm.nih.gov/pubmed/33435150
http://dx.doi.org/10.3390/cells10010117
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author Minciacchi, Valentina R.
Kumar, Rahul
Krause, Daniela S.
author_facet Minciacchi, Valentina R.
Kumar, Rahul
Krause, Daniela S.
author_sort Minciacchi, Valentina R.
collection PubMed
description Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
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spelling pubmed-78274822021-01-25 Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future Minciacchi, Valentina R. Kumar, Rahul Krause, Daniela S. Cells Review Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage. MDPI 2021-01-10 /pmc/articles/PMC7827482/ /pubmed/33435150 http://dx.doi.org/10.3390/cells10010117 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Minciacchi, Valentina R.
Kumar, Rahul
Krause, Daniela S.
Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
title Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
title_full Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
title_fullStr Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
title_full_unstemmed Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
title_short Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future
title_sort chronic myeloid leukemia: a model disease of the past, present and future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827482/
https://www.ncbi.nlm.nih.gov/pubmed/33435150
http://dx.doi.org/10.3390/cells10010117
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