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Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis

SIMPLE SUMMARY: Chimeric antigen receptor-modified T cells (CAR-T) have shown great success in the treatment of B-cell leukemia. However, their efficacy is compromised in B-cell-derived lymphoma and solid tumors. Optimization of CAR design to improve in vivo persistence is a focus of current CAR-T c...

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Detalles Bibliográficos
Autores principales:	Wang, Haiyong, Han, Ping, Qi, Xinyue, Li, Fanlin, Li, Min, Fan, Lilv, Zhang, Huihui, Zhang, Xiaoqing, Yang, Xuanming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827522/ https://www.ncbi.nlm.nih.gov/pubmed/33429845 http://dx.doi.org/10.3390/cancers13020197

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