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Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders

Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to s...

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Autores principales: Catanesi, Mariano, Caioni, Giulia, Castelli, Vanessa, Benedetti, Elisabetta, d’Angelo, Michele, Cimini, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827849/
https://www.ncbi.nlm.nih.gov/pubmed/33430021
http://dx.doi.org/10.3390/md19010024
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author Catanesi, Mariano
Caioni, Giulia
Castelli, Vanessa
Benedetti, Elisabetta
d’Angelo, Michele
Cimini, Annamaria
author_facet Catanesi, Mariano
Caioni, Giulia
Castelli, Vanessa
Benedetti, Elisabetta
d’Angelo, Michele
Cimini, Annamaria
author_sort Catanesi, Mariano
collection PubMed
description Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties.
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spelling pubmed-78278492021-01-25 Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders Catanesi, Mariano Caioni, Giulia Castelli, Vanessa Benedetti, Elisabetta d’Angelo, Michele Cimini, Annamaria Mar Drugs Review Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. MDPI 2021-01-08 /pmc/articles/PMC7827849/ /pubmed/33430021 http://dx.doi.org/10.3390/md19010024 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Catanesi, Mariano
Caioni, Giulia
Castelli, Vanessa
Benedetti, Elisabetta
d’Angelo, Michele
Cimini, Annamaria
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
title Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
title_full Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
title_fullStr Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
title_full_unstemmed Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
title_short Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
title_sort benefits under the sea: the role of marine compounds in neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827849/
https://www.ncbi.nlm.nih.gov/pubmed/33430021
http://dx.doi.org/10.3390/md19010024
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