Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile...

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Detalles Bibliográficos
Autores principales: Sun, Jiayu, Li, Jie, Sun, Hongbao, Li, Chunling, Wu, Haoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827859/
https://www.ncbi.nlm.nih.gov/pubmed/33429851
http://dx.doi.org/10.3390/molecules26020276
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author Sun, Jiayu
Li, Jie
Sun, Hongbao
Li, Chunling
Wu, Haoxing
author_facet Sun, Jiayu
Li, Jie
Sun, Hongbao
Li, Chunling
Wu, Haoxing
author_sort Sun, Jiayu
collection PubMed
description Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile to generate stable substrates suitable for bioorthogonal tetrazine ligation.
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spelling pubmed-78278592021-01-25 Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation Sun, Jiayu Li, Jie Sun, Hongbao Li, Chunling Wu, Haoxing Molecules Article Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile to generate stable substrates suitable for bioorthogonal tetrazine ligation. MDPI 2021-01-08 /pmc/articles/PMC7827859/ /pubmed/33429851 http://dx.doi.org/10.3390/molecules26020276 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Jiayu
Li, Jie
Sun, Hongbao
Li, Chunling
Wu, Haoxing
Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
title Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
title_full Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
title_fullStr Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
title_full_unstemmed Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
title_short Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
title_sort concise synthesis of functionalized cyclobutene analogues for bioorthogonal tetrazine ligation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827859/
https://www.ncbi.nlm.nih.gov/pubmed/33429851
http://dx.doi.org/10.3390/molecules26020276
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AT lichunling concisesynthesisoffunctionalizedcyclobuteneanaloguesforbioorthogonaltetrazineligation
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