Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile...

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Detalles Bibliográficos
Autores principales: Sun, Jiayu, Li, Jie, Sun, Hongbao, Li, Chunling, Wu, Haoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827859/
https://www.ncbi.nlm.nih.gov/pubmed/33429851
http://dx.doi.org/10.3390/molecules26020276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827859/
https://www.ncbi.nlm.nih.gov/pubmed/33429851
http://dx.doi.org/10.3390/molecules26020276

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