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Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is a disease of unknown etiology, but half-dose photodynamic therapy (hPDT) is well known to be effective for CSC. Infrared reflectance (IR) has been shown to be effective for detecting retinal pigmented epithelial and choroidal lesions, but no reports have foc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827861/ https://www.ncbi.nlm.nih.gov/pubmed/33440827 http://dx.doi.org/10.3390/ph14010053 |
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author | Wakatsuki, Yu Tanaka, Koji Mori, Ryusaburo Furuya, Koichi Kawamura, Akiyuki Nakashizuka, Hiroyuki |
author_facet | Wakatsuki, Yu Tanaka, Koji Mori, Ryusaburo Furuya, Koichi Kawamura, Akiyuki Nakashizuka, Hiroyuki |
author_sort | Wakatsuki, Yu |
collection | PubMed |
description | Central serous chorioretinopathy (CSC) is a disease of unknown etiology, but half-dose photodynamic therapy (hPDT) is well known to be effective for CSC. Infrared reflectance (IR) has been shown to be effective for detecting retinal pigmented epithelial and choroidal lesions, but no reports have focused on chorioretinal changes using IR images after as compared to before hPDT. This study aimed to clarify the features of IR images as well as retinal and choroidal morphological changes before and after treatment with verteporfin hPDT for CSC. We also examined prognostic factors associated with CSC treatment. This was a retrospective study that included 140 eyes of 140 patients (male/female ratio 122:18, mean age 53.4 ± 10.8 years) diagnosed with CSC who underwent hPDT in our hospital during the period from April 2015 to December 2018. We determined changes in visual acuity, therapeutic efficacy, central retinal thickness (CRT), central choroidal thickness (CCT), and IR images at one and three months after hPDT as compared to before treatment. Dry macula was defined as a complete resolution of serous retinal detachment after hPDT. History of smoking, disease duration, presence of drusen, presence of retinal pigment epithelium abnormalities, type of fluorescein angiographic leakage, and presence of choroidal vascular hyperpermeability were investigated as prognostic factors associated with treatment efficacy. CRT and CCT were measured using optical coherence tomography (Spectralis HRA-2; Heidelberg Engineering), and IR images after versus before treatment were compared using ImageJ software (version 1.52) to calculate the mean luminance for a 3 × 3 mm area in the macula. Compared with the values before treatment, CCT, CRT, and visual acuity showed significant improvements at one and three months after treatment, and the mean luminance of IR images was also significantly increased. Furthermore, the luminance on IR images tended to rise, though the values at one month and three months after treatment did not differ significantly. Disease duration was significantly associated with dry macula one month after treatment, and visual acuity and CRT before hPDT were both significantly related to dry macula three months after treatment. IR images tended to improve over time, from before treatment through one and three months after hPDT. |
format | Online Article Text |
id | pubmed-7827861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78278612021-01-25 Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy Wakatsuki, Yu Tanaka, Koji Mori, Ryusaburo Furuya, Koichi Kawamura, Akiyuki Nakashizuka, Hiroyuki Pharmaceuticals (Basel) Article Central serous chorioretinopathy (CSC) is a disease of unknown etiology, but half-dose photodynamic therapy (hPDT) is well known to be effective for CSC. Infrared reflectance (IR) has been shown to be effective for detecting retinal pigmented epithelial and choroidal lesions, but no reports have focused on chorioretinal changes using IR images after as compared to before hPDT. This study aimed to clarify the features of IR images as well as retinal and choroidal morphological changes before and after treatment with verteporfin hPDT for CSC. We also examined prognostic factors associated with CSC treatment. This was a retrospective study that included 140 eyes of 140 patients (male/female ratio 122:18, mean age 53.4 ± 10.8 years) diagnosed with CSC who underwent hPDT in our hospital during the period from April 2015 to December 2018. We determined changes in visual acuity, therapeutic efficacy, central retinal thickness (CRT), central choroidal thickness (CCT), and IR images at one and three months after hPDT as compared to before treatment. Dry macula was defined as a complete resolution of serous retinal detachment after hPDT. History of smoking, disease duration, presence of drusen, presence of retinal pigment epithelium abnormalities, type of fluorescein angiographic leakage, and presence of choroidal vascular hyperpermeability were investigated as prognostic factors associated with treatment efficacy. CRT and CCT were measured using optical coherence tomography (Spectralis HRA-2; Heidelberg Engineering), and IR images after versus before treatment were compared using ImageJ software (version 1.52) to calculate the mean luminance for a 3 × 3 mm area in the macula. Compared with the values before treatment, CCT, CRT, and visual acuity showed significant improvements at one and three months after treatment, and the mean luminance of IR images was also significantly increased. Furthermore, the luminance on IR images tended to rise, though the values at one month and three months after treatment did not differ significantly. Disease duration was significantly associated with dry macula one month after treatment, and visual acuity and CRT before hPDT were both significantly related to dry macula three months after treatment. IR images tended to improve over time, from before treatment through one and three months after hPDT. MDPI 2021-01-11 /pmc/articles/PMC7827861/ /pubmed/33440827 http://dx.doi.org/10.3390/ph14010053 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wakatsuki, Yu Tanaka, Koji Mori, Ryusaburo Furuya, Koichi Kawamura, Akiyuki Nakashizuka, Hiroyuki Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy |
title | Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy |
title_full | Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy |
title_fullStr | Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy |
title_full_unstemmed | Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy |
title_short | Morphological Changes and Prognostic Factors before and after Photodynamic Therapy for Central Serous Chorioretinopathy |
title_sort | morphological changes and prognostic factors before and after photodynamic therapy for central serous chorioretinopathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827861/ https://www.ncbi.nlm.nih.gov/pubmed/33440827 http://dx.doi.org/10.3390/ph14010053 |
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