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Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review

As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between...

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Autores principales: Hager, Amber, Mager, Diana, Robert, Cheri, Nicholas, David, Gilmour, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827867/
https://www.ncbi.nlm.nih.gov/pubmed/33445652
http://dx.doi.org/10.3390/diagnostics11010111
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author Hager, Amber
Mager, Diana
Robert, Cheri
Nicholas, David
Gilmour, Susan
author_facet Hager, Amber
Mager, Diana
Robert, Cheri
Nicholas, David
Gilmour, Susan
author_sort Hager, Amber
collection PubMed
description As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8–3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014–2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement (p > 0.05) and did not change over four years (p > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social–emotional sub-domain (p = 0.03) and the child reported lower sub-domain scores related to coping and adjustment (p = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child–parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL.
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spelling pubmed-78278672021-01-25 Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review Hager, Amber Mager, Diana Robert, Cheri Nicholas, David Gilmour, Susan Diagnostics (Basel) Article As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8–3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014–2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement (p > 0.05) and did not change over four years (p > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social–emotional sub-domain (p = 0.03) and the child reported lower sub-domain scores related to coping and adjustment (p = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child–parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL. MDPI 2021-01-12 /pmc/articles/PMC7827867/ /pubmed/33445652 http://dx.doi.org/10.3390/diagnostics11010111 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hager, Amber
Mager, Diana
Robert, Cheri
Nicholas, David
Gilmour, Susan
Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
title Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
title_full Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
title_fullStr Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
title_full_unstemmed Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
title_short Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
title_sort health-related quality of life 10 years after liver transplantation: a longitudinal retrospective review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827867/
https://www.ncbi.nlm.nih.gov/pubmed/33445652
http://dx.doi.org/10.3390/diagnostics11010111
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