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Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review
As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827867/ https://www.ncbi.nlm.nih.gov/pubmed/33445652 http://dx.doi.org/10.3390/diagnostics11010111 |
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author | Hager, Amber Mager, Diana Robert, Cheri Nicholas, David Gilmour, Susan |
author_facet | Hager, Amber Mager, Diana Robert, Cheri Nicholas, David Gilmour, Susan |
author_sort | Hager, Amber |
collection | PubMed |
description | As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8–3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014–2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement (p > 0.05) and did not change over four years (p > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social–emotional sub-domain (p = 0.03) and the child reported lower sub-domain scores related to coping and adjustment (p = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child–parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL. |
format | Online Article Text |
id | pubmed-7827867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78278672021-01-25 Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review Hager, Amber Mager, Diana Robert, Cheri Nicholas, David Gilmour, Susan Diagnostics (Basel) Article As survival post-liver transplantation (LTx) improves, it becomes increasingly important to understand how long-term health-related quality of life (HRQOL) is impacted. This was a longitudinal review examining HRQOL measured by Pediatric Liver Transplant Quality of Life (PeLTQL) in children between 8-17 years who underwent LTx (1.4 [0.8–3.3] years) at least one year prior to assessment. Demographic, medical, anthropometric, and HRQOL data (self-reported and parent proxy) were retrospectively collected over four years (2014–2017) at annual LTx clinic visits. The study included 35 patients (18M, 17F) and their parents/guardians. Parent-proxy and child PeLTQL scores (total, subdomain) showed good to excellent agreement (p > 0.05) and did not change over four years (p > 0.05). Younger age (<12 years) and Caucasian ancestry were associated with higher parental and self-reported perceptions of HRQOL, respectively (future health, coping and adjustment, total scores). Parent perceived lower HRQOL in social–emotional sub-domain (p = 0.03) and the child reported lower sub-domain scores related to coping and adjustment (p = 0.04) when the child was noted to have co-morbid conditions related to mental health and neurocognitive development (25.7%). While child–parent perceptions of HRQOL in a multi-ethnic population of pediatric LTx recipients remain unchanged 10 years post-LTx, adolescents of non-Caucasian ancestry remain a population at risk for lower HRQOL. MDPI 2021-01-12 /pmc/articles/PMC7827867/ /pubmed/33445652 http://dx.doi.org/10.3390/diagnostics11010111 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hager, Amber Mager, Diana Robert, Cheri Nicholas, David Gilmour, Susan Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
title | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
title_full | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
title_fullStr | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
title_full_unstemmed | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
title_short | Health-Related Quality of Life 10 Years after Liver Transplantation: A Longitudinal Retrospective Review |
title_sort | health-related quality of life 10 years after liver transplantation: a longitudinal retrospective review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827867/ https://www.ncbi.nlm.nih.gov/pubmed/33445652 http://dx.doi.org/10.3390/diagnostics11010111 |
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